CAJ | 학술논문

目的：探索孤独症患儿刻板行为与运动前区静息态功能连接的关联。方法选择39例孤独症患儿作为病例组,性别、年龄、教育程度匹配的健康被试者42例作为对照。对81例被试者进行量表评价及静息态功能磁共振成像数据采集,数据预处理之后,以左右侧运动前区为种子点分别作基于种子点的功能连接分析,比较组间差异,并在差异的基础上进行功能连接与行为量表指标的关联。结果孤独症患儿左侧运动前区与后扣带回/楔前叶连接显著增强、与左侧岛叶连接显著减低(P <0.05,FDR 校正)；并且孤独症患儿组左侧运动前区与岛叶的功能连接与刻板行为指标呈显著负相关(P <0.05)。结论孤独症患儿的运动前区功能连接的失衡可能是其刻板行为的机制之一,这种失衡表现为对外界凸显刺激的感知减弱和注意的缺陷。
목적：탐색고독증환인각판행위여운동전구정식태공능련접적관련。방법선택39례고독증환인작위병례조,성별、년령、교육정도필배적건강피시자42례작위대조。대81례피시자진행량표평개급정식태공능자공진성상수거채집,수거예처리지후,이좌우측운동전구위충자점분별작기우충자점적공능련접분석,비교조간차이,병재차이적기출상진행공능련접여행위량표지표적관련。결과고독증환인좌측운동전구여후구대회/설전협련접현저증강、여좌측도협련접현저감저(P <0.05,FDR 교정)；병차고독증환인조좌측운동전구여도협적공능련접여각판행위지표정현저부상관(P <0.05)。결론고독증환인적운동전구공능련접적실형가능시기각판행위적궤제지일,저충실형표현위대외계철현자격적감지감약화주의적결함。
Objective To probe the relationship between the connectivity of premotor area detected by resting state functional MRI and stereotyped behavior of ASD.Methods 39 children patients with ASD and 42 healthy controls with matched age,sex and IQ were recruited.All the 81 subjects performed scaling with behavior scale index and underwent resting-state fMRI scans.After the fMRI data precession,the premotors in left and right sides were selected as ROI seeds to perform functional connectivity.Results Compared with healthy controls,children patients showed significant increased connectivity between the left premotor area and posterior cingulate cortex,as well as decreased functional connectivity between the left premotor area and the left insula.In addition, a negative linear correlation was showed between the connectivity of the left premotor and the insula and the behavioral scores.Con-clusion Imbalanced premotor functional connectivity may be one possible mechanism of stereotyped behavior of ASD,representing an attention deficit and/or impaired sensory perception to the external salient stimuli.