实用放射学杂志
實用放射學雜誌
실용방사학잡지
JOURNAL OF PRACTICAL RADIOLOGY
2015年
8期
1269-1272,1277
,共5页
赵娓娓%全志永%陈燕%王珂%任芳%赵青川%文娣娣%侯炜寰%潘奇%李娜%任静%宦怡
趙娓娓%全誌永%陳燕%王珂%任芳%趙青川%文娣娣%侯煒寰%潘奇%李娜%任靜%宦怡
조미미%전지영%진연%왕가%임방%조청천%문제제%후위환%반기%리나%임정%환이
胃癌%扩散加权成像%表观扩散系数%化疗疗效
胃癌%擴散加權成像%錶觀擴散繫數%化療療效
위암%확산가권성상%표관확산계수%화료료효
gastric carcinoma%diffusion-weighted imaging%apparent diffusion coefficient%chemotherapy response
目的：探讨扩散加权成像(DWI)及表观扩散系数(ADC)在进展期胃癌化疗疗效动态监测中的应用价值。方法42例病理证实的进展期胃癌患者，分别于化疗前、化疗后3 d、7 d、30 d 和60 d 行 T2 WI-MRI、DWI-MRI 检查。测量化疗前和化疗后60 d 横轴位肿瘤最大径，以及化疗前及化疗后各时间点肿瘤 ADC 值，分析各疗效组化疗前和化疗后不同时间点 ADC 值差异。结果部分有效(PR)组化疗前、化疗后3 d、7 d、30 d、60 d ADC 值呈上升趋势，化疗前与化疗后各时间点的 ADC 值差异有统计学意义(P <0.05)；稳定(SD)组化疗前、化疗后3 d、7 d、30 d ADC 值变化呈上升趋势，于化疗后60 d ADC 值有所下降，化疗前与化疗后各时间点的 ADC 值差异有统计学意义(P <0.05)。结论 DWI 及 ADC 值可动态观察和早期定量监测进展期胃癌化疗疗效。
目的：探討擴散加權成像(DWI)及錶觀擴散繫數(ADC)在進展期胃癌化療療效動態鑑測中的應用價值。方法42例病理證實的進展期胃癌患者，分彆于化療前、化療後3 d、7 d、30 d 和60 d 行 T2 WI-MRI、DWI-MRI 檢查。測量化療前和化療後60 d 橫軸位腫瘤最大徑，以及化療前及化療後各時間點腫瘤 ADC 值，分析各療效組化療前和化療後不同時間點 ADC 值差異。結果部分有效(PR)組化療前、化療後3 d、7 d、30 d、60 d ADC 值呈上升趨勢，化療前與化療後各時間點的 ADC 值差異有統計學意義(P <0.05)；穩定(SD)組化療前、化療後3 d、7 d、30 d ADC 值變化呈上升趨勢，于化療後60 d ADC 值有所下降，化療前與化療後各時間點的 ADC 值差異有統計學意義(P <0.05)。結論 DWI 及 ADC 值可動態觀察和早期定量鑑測進展期胃癌化療療效。
목적：탐토확산가권성상(DWI)급표관확산계수(ADC)재진전기위암화료료효동태감측중적응용개치。방법42례병리증실적진전기위암환자，분별우화료전、화료후3 d、7 d、30 d 화60 d 행 T2 WI-MRI、DWI-MRI 검사。측양화료전화화료후60 d 횡축위종류최대경，이급화료전급화료후각시간점종류 ADC 치，분석각료효조화료전화화료후불동시간점 ADC 치차이。결과부분유효(PR)조화료전、화료후3 d、7 d、30 d、60 d ADC 치정상승추세，화료전여화료후각시간점적 ADC 치차이유통계학의의(P <0.05)；은정(SD)조화료전、화료후3 d、7 d、30 d ADC 치변화정상승추세，우화료후60 d ADC 치유소하강，화료전여화료후각시간점적 ADC 치차이유통계학의의(P <0.05)。결론 DWI 급 ADC 치가동태관찰화조기정량감측진전기위암화료료효。
Objective To evaluate the value of DWI and ADC value in monitoring the chemotherapy response of advanced gastric carcinoma dynamically.Methods 42 advanced gastric carcinoma patients who were confirmed by histopathology underwent T2 WI and DWI examinations at pre-chemotherapy,post-chemotherapy 3 d,7 d,30 d and 60 d respectively.The longest diameters of tumor pre-chemotherapy and post-chemotherapy 60 d were measured on axial T2 WI,meanwhile the ADC values at different time points were calculated.The mean ADC value among pre-and post-chemotherapy of each group (PR and SD)was compared.Results The ADC value of PR group increased gradually.The mean ADC value before therapy was statistically lower than those at differ-ent time points post-chemotherapy (P < 0.05).The ADC value of SD group increased gradually from pre-chemotherapy to post-chemotherapy 30 d,and then the ADC value decreased at post-chemotherapy 60 d.The differences of the mean ADC values in differ-ent time points were statistically significant (P < 0.05).Conclusion DWI and ADC value can dynamically,quantitatively and early detect and monitor the chemotherapy response of advanced gastric carcinoma.
