CAJ | 학술논문

人乳头瘤病毒（HPV）感染引起人皮肤和黏膜的多种良、恶性病变，如尖锐湿疣、宫颈上皮内瘤样变及宫颈癌等。HPV感染后可刺激宿主免疫系统（特异性免疫和非特异性免疫）产生一定的免疫应答；HPV亦通过多种免疫逃逸机制逃避宿主免疫系统的监视与清除。HPV与宿主免疫系统之间的相互作用决定了HPV感染后不同的临床表现（临床无症状或病变持续存在甚至发生癌变）。该文综述了HPV感染后宿主免疫反应及HPV免疫逃逸机制的研究进展。
인유두류병독（HPV）감염인기인피부화점막적다충량、악성병변，여첨예습우、궁경상피내류양변급궁경암등。HPV감염후가자격숙주면역계통（특이성면역화비특이성면역）산생일정적면역응답；HPV역통과다충면역도일궤제도피숙주면역계통적감시여청제。HPV여숙주면역계통지간적상호작용결정료HPV감염후불동적림상표현（림상무증상혹병변지속존재심지발생암변）。해문종술료HPV감염후숙주면역반응급HPV면역도일궤제적연구진전。
Human papillomavirus (HPV) infection can cause a variety of benign and malignant lesions of skin and mucosa, such as condyloma acuminatum, cervical intraepithelial neoplasia (CIN) and cervical cancer. HPV infection can stimulate the host’s immune system (specific immunity and nonspecific immunity) that responses to some certain. HPV also can evade the surveillance and clearing of the host’s immune system through a variety of immune escape mechanisms. The interaction between HPV and the host immune system determines the different clinical manifestations of HPV infection (without clinical symptoms, lesions persist or even cancer). This paper will review the research progress of host’s immune response and immune escape mechanism after HPV infection.