CAJ | 학술논문

β-葡聚糖是真菌胞壁的主要多糖成分。天然免疫系统识别这一成分后触发髓系细胞的免疫应答反应，杀伤和清除入侵微生物。该文主要介绍天然免疫细胞的模式识别受体dectin-1与β-葡聚糖的特性以及它们通过何种信号传导途径激活天然免疫系统。对β-葡聚糖和dectin-1的研究必将为研制抗真菌免疫制剂和抗真菌药物靶点提供崭新的思路。
β-포취당시진균포벽적주요다당성분。천연면역계통식별저일성분후촉발수계세포적면역응답반응，살상화청제입침미생물。해문주요개소천연면역세포적모식식별수체dectin-1여β-포취당적특성이급타문통과하충신호전도도경격활천연면역계통。대β-포취당화dectin-1적연구필장위연제항진균면역제제화항진균약물파점제공참신적사로。
Polysaccharide such as β-glucans is the major component of fungal surfaces. Recognition of these molecules by the innate immune system triggers inlfammatory responses and activation of microbicidal mechanisms mediated by myeloid cells. This review will depict in details how the property of β-glucans and their receptor dectin-1 contributes to its immunostimulating effect in hosts and the potential uses ofβ-glucans by elucidating the dectin-1 signal transduction pathway. These studies will undoubtedly open a new research area on their potential therapeutic applications, including immunostimulants for antifungal agents.