CAJ | 학술논문

目的：观察小剂量泼尼松干预5-氨基酮戊酸光动力治疗尖锐湿疣过程中所产生疼痛的作用。方法试验组51例，在照光前0.5 h给予小剂量泼尼松20 mg口服；对照组49例，照光前不服用任何药物。采用NRS（numeric rating scale）评分法记录两组患者在照光3、5、10、15、20 min的疼痛分值，比较两组5个时间点中最高的疼痛评分值；并于末次治疗后1、2、4、12、24周进行疗效评估，比较两组治疗后的复发情况。结果照光期间所产生的疼痛以局部浅表的灼痛和刺痛为主要特征，两组最高疼痛评分中位数比较，差异有统计学意义（P＜0.05）。试验组和对照组治愈率分别为80.4%和81.6%，复发率分别为19.6%和18.4%，差异均无统计学意义（P＞0.05）。结论小剂量泼尼松可缓解5-氨基酮戊酸光动力治疗尖锐湿疣照光过程中所产生的疼痛，不影响临床疗效。
목적：관찰소제량발니송간예5-안기동무산광동력치료첨예습우과정중소산생동통적작용。방법시험조51례，재조광전0.5 h급여소제량발니송20 mg구복；대조조49례，조광전불복용임하약물。채용NRS（numeric rating scale）평분법기록량조환자재조광3、5、10、15、20 min적동통분치，비교량조5개시간점중최고적동통평분치；병우말차치료후1、2、4、12、24주진행료효평고，비교량조치료후적복발정황。결과조광기간소산생적동통이국부천표적작통화자통위주요특정，량조최고동통평분중위수비교，차이유통계학의의（P＜0.05）。시험조화대조조치유솔분별위80.4%화81.6%，복발솔분별위19.6%화18.4%，차이균무통계학의의（P＞0.05）。결론소제량발니송가완해5-안기동무산광동력치료첨예습우조광과정중소산생적동통，불영향림상료효。
Objective To observe the effects of low-dose prednisone for pain control during 5-aminolevulinic acid-photodynamic therapy of condyloma acuminatum. Methods The treatment group (51cases) received low-dose prednisone 20mg about 30 minutes before the irradiation, the control group (49 cases) given not any drugs before irradiation. Pain scores were recorded using the numeric rating scale (NRS) at pre-deifned assessments (at 3, 5, 10, 15 and 20 minutes after the start of treatment). The highest pain scores of the two groups at ifve assessment points were compared. The clinical efifcacy and recurrence rates after the last treatment (1st, 2nd, 4th, 12th and 24th week) were evaluated. Results The pain dominated by characteristics such as burning and pricking was almost local and superifcial. The difference was statistically signiifcant about the median highest pain scores (P<0.05). The difference had no statistical signiifcance (P>0.05) for the comparison of the cure rate (treatment group 80.4%, control group 81.6%) and recurrence rates (treatment group 19.6%, control group18.4%). Conclusion Low-dose prednisone can relieve the pain during irradiation of 5-aminolevulinic acid-photodynamic therapy and does not affect the clinical curative effect.