CAJ | 학술논문

目的：观察5-氨基酮戊酸光动力疗法（ALA-PDT）的不同治疗方案治疗中重度痤疮的有效性与安全性。方法60例中重度痤疮患者，随机分为3组，分别接受1个基础疗程、1个基础疗程联合1个维持疗程和2个基础疗程治疗，治疗结束后1、3、6、12个月对患者进行访视，记录皮损消退情况及不良反应。结果3个月后3组患者治疗的有效率分别为80%、90%和88.2%；6个月后3组患者治疗的有效率分别为55%、85%和88.2%。12个月后3组复发率分别为60%、20%和52.9%。结论 ALA-PDT治疗中重度痤疮安全、有效。2个基础疗程和1个基础疗程联合1个维持疗程方案均获得较好的疗效，且基础疗程联合维持疗程的治疗复发率最低。
목적：관찰5-안기동무산광동력요법（ALA-PDT）적불동치료방안치료중중도좌창적유효성여안전성。방법60례중중도좌창환자，수궤분위3조，분별접수1개기출료정、1개기출료정연합1개유지료정화2개기출료정치료，치료결속후1、3、6、12개월대환자진행방시，기록피손소퇴정황급불량반응。결과3개월후3조환자치료적유효솔분별위80%、90%화88.2%；6개월후3조환자치료적유효솔분별위55%、85%화88.2%。12개월후3조복발솔분별위60%、20%화52.9%。결론 ALA-PDT치료중중도좌창안전、유효。2개기출료정화1개기출료정연합1개유지료정방안균획득교호적료효，차기출료정연합유지료정적치료복발솔최저。
Objective To observe the efficacy and safety of three different methods of 5-aminolevulinic acid photodynamic therapy(ALA-PDT) to treat moderate to severe acne. Methods Sixty patients with moderate to severe acne were randomly divided into three groups and treated with different strategies. Group A were treated with one basic course. Group B were treated with one basic course and one maintaining course. Group C were treated with two basic courses. The effect and adverse reaction were evaluated on 1, 3, 6 and 12-month visit after the last treatment. Results The effective rates of three groups were 80%, 90% and 88.2%respectively on 3-month visit, and were 55%, 85%, 88.2%respectively on 6-month visit. The recurrence rates were 60%, 20% and 52.9% respectively on 12-month visit. Conclusion ALA-PDT is safe and effective for moderate to severe acne. Two basic courses or one basic course with one maintaining course were both effect but one basic course with one maintaining course has lowest recurrence rate.