CAJ | 학술논문

目的：回顾分析全身治疗及综合皮损处理技术救治大疱性表皮松解坏死型药疹的疗效。方法在抗休克、抗感染、抗过敏、治疗原发病灶等系统治疗的基础上，采用脱细胞真皮、纳米银敷料、人工细胞愈合膜、生长因子等新型敷料和药物以及悬浮床、烧伤创面治疗仪、半导体激光等设备治疗皮损。结果22例患者中19例治愈出院，1例死于肺动脉栓塞，2例死于感染性休克。结论全身治疗可以维持患者内环境的稳定、控制皮损发展、减少感染的发生；悬浮床、气垫床可以避免压迫导致创面加深；纳米银敷料、活性碳敷料可以防治创面感染；脱细胞真皮包扎治疗、烧伤创面治疗仪、半导体激光、生长因子的应用可以加速创面愈合，减轻患者痛苦。
목적：회고분석전신치료급종합피손처리기술구치대포성표피송해배사형약진적료효。방법재항휴극、항감염、항과민、치료원발병조등계통치료적기출상，채용탈세포진피、납미은부료、인공세포유합막、생장인자등신형부료화약물이급현부상、소상창면치료의、반도체격광등설비치료피손。결과22례환자중19례치유출원，1례사우폐동맥전새，2례사우감염성휴극。결론전신치료가이유지환자내배경적은정、공제피손발전、감소감염적발생；현부상、기점상가이피면압박도치창면가심；납미은부료、활성탄부료가이방치창면감염；탈세포진피포찰치료、소상창면치료의、반도체격광、생장인자적응용가이가속창면유합，감경환자통고。
Objective To retrospectively analyze the effects of management techniques including systemic and topical therapeutic treatments for patients with toxic epidermal necrolysis(TEN). Methods The comprehensive therapy based on systemic treatments such as anti-shock, anti-infection, anti-allergic drug and primary disease treatment. Topical treatments for skin lesions included applications of acellular dermal sheet, nano silver dressing, artiifcial cellular healing membrane, growth factor, suspension bed, wound therapeutic apparatus and semi-conductive laser. Results Among these 22 patients, 19 patients were cured and discharged, 1 patient died from pulmonary embolism and 2 patients died from septic shock. Conclusions Systemic measures play key roles in maintaining stability of internal environment, which may control the progression of skin lesions and decrease the incidence of infection. Topical measures also play key roles in TEN treatment, e.g. relieving wound deepening by application of suspension bed, decreasing the incidence of wound infection by nano silver dressing, accelerating wound healing and reducing the pain of patients by application of acellular dermal sheet, artiifcial cellular healing membrane, growth factor and semi-conductive laser, etc.