CAJ | 학술논문

目的：观察露明斯 TM（十肽-12）治疗黄褐斑的安全性及有效性。方法选取30例黄褐斑受试者，以治疗前为基线，通过治疗前后进行自身对照。每日使用露明斯 TM亮白组合于面部，共使用6～8周。分别于治疗前、治疗后1个月、3个月拍摄VISIA图像观察疗效，并由临床医生根据患者黄褐斑面积及颜色进行4级评分，计算总积分及积分下降指数；由受试者对疗效进行满意度评价，共随访6个月。结果治疗3个月，与治疗前相比，色斑痊愈5例，治愈率为16.7%；显效14例（46.7%）；好转7例（23.3%）；无效4例（13.3%），总有效率为86.7%。随访6个月，5例（16.7%）患者轻度复发。治疗结束后60%以上的受试者表示对治疗满意或非常满意。未见明显不良反应。结论露明斯 TM治疗中国人面部黄褐斑效果较好、安全性高。
목적：관찰로명사 TM（십태-12）치료황갈반적안전성급유효성。방법선취30례황갈반수시자，이치료전위기선，통과치료전후진행자신대조。매일사용로명사 TM량백조합우면부，공사용6～8주。분별우치료전、치료후1개월、3개월박섭VISIA도상관찰료효，병유림상의생근거환자황갈반면적급안색진행4급평분，계산총적분급적분하강지수；유수시자대료효진행만의도평개，공수방6개월。결과치료3개월，여치료전상비，색반전유5례，치유솔위16.7%；현효14례（46.7%）；호전7례（23.3%）；무효4례（13.3%），총유효솔위86.7%。수방6개월，5례（16.7%）환자경도복발。치료결속후60%이상적수시자표시대치료만의혹비상만의。미견명현불량반응。결론로명사 TM치료중국인면부황갈반효과교호、안전성고。
Objective To investigate the efifcacy and safety of lumixylTM (decapeptide-12) for melasma therapy. Methods Total 30 volunteers with melasma were enrolled in this study by self-control before and after the treatment. Subjects received a total of lumixylTM daily for 6 to 8 weeks, and then the efifcacy at 1 month and 3 months after the treatment were evaluated by digital photography and VISIA by both the doctors and volunteers, followed up for 6 months. Results From the baseline to to 3 months after of treatment, 5 case recovered (16.7%), signiifcant improvement 14 case (46.7%), slight improvement 7 case (23.3%), no change 4 case (13.3%). The total efifciency was 86.7%. There was a signiifcant statistical difference between before and after the treatment (P<0.05). Follow-up 6 months, 5 cases (16.7%) had mild relapse. Over 60%subjects considered satisfactory or very satisfactory after the course of treatment. No signiifcant adverse reactions occurred. Conclusion LumixylTM is safe and effective in the treatment of melasma in Chinese.