CAJ | 학술논문

目的：：调查安徽省阜阳地区门诊患者人乳头瘤病毒( HPV)感染情况，分析该地区宫颈HPV 23种基因亚型感染及分布情况。方法：对2140例接受妇科HPV检测的患者进行病理诊断，采用基因芯片技术导流杂交方法进行HPV 亚型分型检测。结果：HPV总感染率为28.8%，单一感染占58.3%，高危型HPV感染率为22.9%。最常见的HPV感染为HPV16(21.4%)、HPV58(9.5%)、HPV52(7.3%)、HPV31(6.0%)、HPV18(5.8%)；高危型HPV感染率和HPV各亚型感染率在各年龄组分布差异无统计学意义(P>0.05)。结论：该地区妇女宫颈HPV感染以HPV16、52、58型为主，基因亚型分布具有区域特异性。
목적：：조사안휘성부양지구문진환자인유두류병독( HPV)감염정황，분석해지구궁경HPV 23충기인아형감염급분포정황。방법：대2140례접수부과HPV검측적환자진행병리진단，채용기인심편기술도류잡교방법진행HPV 아형분형검측。결과：HPV총감염솔위28.8%，단일감염점58.3%，고위형HPV감염솔위22.9%。최상견적HPV감염위HPV16(21.4%)、HPV58(9.5%)、HPV52(7.3%)、HPV31(6.0%)、HPV18(5.8%)；고위형HPV감염솔화HPV각아형감염솔재각년령조분포차이무통계학의의(P>0.05)。결론：해지구부녀궁경HPV감염이HPV16、52、58형위주，기인아형분포구유구역특이성。
Objective:To investigate the human papilloma virus( HPV) infection,and analyze the infection and distribution of 23 HPV subtypes in Fuyang area. Methods:The pathological diagnosis in 2 140 HPV detection women were implemented,the HPV subtype was analyzed using the flow-through hybridization and gene-chip. Results:The total infection,single infection and high-risk infection rates of HPV were 28. 8%,58. 3% and 22. 9%,respectively. The most common types of HPV infections were in turn HPV16(21. 4%),HPV 58(9. 5%),HPV 52(7. 3%),HPV 31(6. 0%) and HPV 18(5. 8%). The difference of the infection rates between high-risk type and each HPV subtype was not statistically significant(P>0. 05). Conclusions:HPV16,52 and 58 types are the main infection type of HPV,the distribution of HPV subtype has regional specificity in Fuyang area.