CAJ | 학술논문

目的：：通过检测慢性阻塞性肺疾病( COPD)患者血浆肾上腺髓质素( ADM)的水平,研究ADM与COPD病情变化的相关性。方法：选择COPD急性加重期患者(加重组)、稳定期患者(稳定组)及健康体检者(对照组)各23例,检测并比较其血浆ADM水平、肺功能、血气分析、血常规。结果：加重组与稳定组血浆ADM水平均明显高于对照组(P<0.01),而加重组血浆ADM水平亦显著高于稳定组(P<0.01)；血浆ADM水平与FEV1.0%、FEV1.0/FVC%和动脉血氧分压均呈显著负相关关系(P<0.01),而与血pH有相关关系(P<0.05)。结论：随着COPD患者病情恶化,ADM代偿性增加,扩张气道,抑制炎症反应,可延缓疾病进展。
목적：：통과검측만성조새성폐질병( COPD)환자혈장신상선수질소( ADM)적수평,연구ADM여COPD병정변화적상관성。방법：선택COPD급성가중기환자(가중조)、은정기환자(은정조)급건강체검자(대조조)각23례,검측병비교기혈장ADM수평、폐공능、혈기분석、혈상규。결과：가중조여은정조혈장ADM수평균명현고우대조조(P<0.01),이가중조혈장ADM수평역현저고우은정조(P<0.01)；혈장ADM수평여FEV1.0%、FEV1.0/FVC%화동맥혈양분압균정현저부상관관계(P<0.01),이여혈pH유상관관계(P<0.05)。결론：수착COPD환자병정악화,ADM대상성증가,확장기도,억제염증반응,가연완질병진전。
Objective:To observe the level of the plasma adrenomedullin ( ADM ) in patients with chronic obstructive pulmonary disease( COPD) ,and investigate the correlation of ADM with COPD. Methods:The patients with COPD were divided into the acute exacerbated COPD group and stable COPD group,and the healthy people were set as the control group(23 cases each group). The plasma ADM levels,pulmonary function,blood gas analysis and blood routine test among three groups were compared. Results:The levels of plasma ADM in acute exacerbated COPD group and stable COPD group were significantly higher than that in control group (P<0. 01),and which in acute exacerbated COPD group was significantly higher than that in stable COPD group(P<0. 01). The level of plasma ADM was significantly negative correlation with the FEV1. 0%,FEV1. 0/FVC% and arterial oxygen partial pressure(P<0.01),but which was correlation with pH value(P < 0. 05). Conclusions:With the deterioration of COPD patients,the ADM compensatory increasing can expand the airway,inhibit the inflammation reaction and delay disease progression.