CAJ | 학술논문

目的：比较瑞舒伐他汀对冠心病合并糖尿病患者非高血脂情况下进行强化降脂治疗的临床效果，提出瑞舒伐他汀的抗炎机制。方法连续入选2014年2月-2015年2月诊断为冠心病合并糖尿病患者124例，根据入院前后顺序将其随机分为他汀组（n=66，瑞舒伐他汀10mg/d）和对照组（n=58），对比分析两组患者治疗前后的空腹血糖、LDL-C、高敏C反应蛋白（hs-CRP）及临床心血管事件发生率。结果他汀组患者的空腹血糖、LDL-C及hs-CRP均显著比对照组降低，差异有统计学意义（P<0.05），临床心血管事件也显著降低(P<0.05)。结论他汀早期强化治疗冠心病合并糖尿病，降低心血管事件，可能与降低炎症水平有关。
목적：비교서서벌타정대관심병합병당뇨병환자비고혈지정황하진행강화강지치료적림상효과，제출서서벌타정적항염궤제。방법련속입선2014년2월-2015년2월진단위관심병합병당뇨병환자124례，근거입원전후순서장기수궤분위타정조（n=66，서서벌타정10mg/d）화대조조（n=58），대비분석량조환자치료전후적공복혈당、LDL-C、고민C반응단백（hs-CRP）급림상심혈관사건발생솔。결과타정조환자적공복혈당、LDL-C급hs-CRP균현저비대조조강저，차이유통계학의의（P<0.05），림상심혈관사건야현저강저(P<0.05)。결론타정조기강화치료관심병합병당뇨병，강저심혈관사건，가능여강저염증수평유관。
Objective To compare the clinical effect of Rosuvastatin to non-high cholesterol patients with coronary heart disease combined diabetes by intensive lipid lowering therapy, and Anti-inflammatory mechanism proposed. Methods 124 patients with coronary heart disease complicated with diabetes were diagnosed and continuously selected from February 2015 to February 2014, according to the order of their hospitalization, patients were randomly divided into two groups:the statin group (n=66, rosuvastatin, 10mg/d) and the control group (n=58). Comparative analysis, on fasting plasma glucose, LDL-C, high-sensitivity C-reactive protein (hs-CRP) and incidence of clinical cardiovascular events, were made between the two groups before and after treatment. Results Fasting glucose, LDL-C and hs-CRP of statin group patients were significantly lower than that of control group, the difference was statistically significant (P<0.05), and incidence of clinical cardiovascular events was significantly lower (P<0.05). Conclusion Early intensive treatment of coronary heart disease combined diabetes with rosuvastatin, incidence of cardiovascular events were reduced, might be associated with levels of inflammation being reduced.