中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
15期
75-77
,共3页
甲状腺乳头癌%血管内皮生长因子C%PTEN
甲狀腺乳頭癌%血管內皮生長因子C%PTEN
갑상선유두암%혈관내피생장인자C%PTEN
Thyroid papillary carcinoma%Vascular endothelial grouth factor C%PTEN
目的：探讨甲状腺乳头癌与血管内皮生长因子C（ VEGF-C）和PTEN蛋白的相关性。方法选取信阳市第一人民医院收治的43例甲状腺乳头癌患者作为研究对象，将其甲状腺乳头癌手术切除标本作为研究组，选取43例甲状腺腺瘤手术切除标本作为对照组，对各组VEGF-C和PTEN蛋白的表达情况进行观察，并分析其与甲状腺乳头癌患者的临床病理特征之间的相关性。结果研究组VEGF-C阳性率为69.8%，PTEN阳性率为46.5%，对照组则分别为4.7%和97.7%，研究组阳性表达率更高（P<0.05），且研究组PTEN阳性表达率明显低于对照组（ P<0.05）。有无淋巴结转移及不同临床TNM分期患者癌组织中的VEGF-C和PTEN阳性表达率比较差异有统计学意义（ P<0.05）。结论 VEGF-C和PTEN的表达改变与甲状腺乳头癌的形成具有相关性，对其进行检测有利于患者临床诊治和预后，具有重要意义。
目的：探討甲狀腺乳頭癌與血管內皮生長因子C（ VEGF-C）和PTEN蛋白的相關性。方法選取信暘市第一人民醫院收治的43例甲狀腺乳頭癌患者作為研究對象，將其甲狀腺乳頭癌手術切除標本作為研究組，選取43例甲狀腺腺瘤手術切除標本作為對照組，對各組VEGF-C和PTEN蛋白的錶達情況進行觀察，併分析其與甲狀腺乳頭癌患者的臨床病理特徵之間的相關性。結果研究組VEGF-C暘性率為69.8%，PTEN暘性率為46.5%，對照組則分彆為4.7%和97.7%，研究組暘性錶達率更高（P<0.05），且研究組PTEN暘性錶達率明顯低于對照組（ P<0.05）。有無淋巴結轉移及不同臨床TNM分期患者癌組織中的VEGF-C和PTEN暘性錶達率比較差異有統計學意義（ P<0.05）。結論 VEGF-C和PTEN的錶達改變與甲狀腺乳頭癌的形成具有相關性，對其進行檢測有利于患者臨床診治和預後，具有重要意義。
목적：탐토갑상선유두암여혈관내피생장인자C（ VEGF-C）화PTEN단백적상관성。방법선취신양시제일인민의원수치적43례갑상선유두암환자작위연구대상，장기갑상선유두암수술절제표본작위연구조，선취43례갑상선선류수술절제표본작위대조조，대각조VEGF-C화PTEN단백적표체정황진행관찰，병분석기여갑상선유두암환자적림상병리특정지간적상관성。결과연구조VEGF-C양성솔위69.8%，PTEN양성솔위46.5%，대조조칙분별위4.7%화97.7%，연구조양성표체솔경고（P<0.05），차연구조PTEN양성표체솔명현저우대조조（ P<0.05）。유무림파결전이급불동림상TNM분기환자암조직중적VEGF-C화PTEN양성표체솔비교차이유통계학의의（ P<0.05）。결론 VEGF-C화PTEN적표체개변여갑상선유두암적형성구유상관성，대기진행검측유리우환자림상진치화예후，구유중요의의。
Objective To study the correlation of thyroid papillary carcinoma with vascular endothelial growth fac-tor C( VEGF-C)and PTEN protein. Methods Forty-five cases of thyroid papillary carcinoma patients in our hospital were selected,and their thyroid papillary carcinoma operation resection specimens were set as study group. 43 cases of thyroid adenoma resection specimens were additionally as contrast group operation. Expression of VEGF-C and PTEN protein in two groups were observed. The correlation between them and the papillary thyroid cancer patients with clinical pathological characteristics were analyzed. Results The positive rate of VEGF-C in the study group was 69. 8% and the positive rate of PTEN was 46. 5%,and they were seperately 4. 7% and 97. 7% in the contrast group. The positive expression rate of VEGF-C in study group was significantly higher ( P<0. 05 ),the positive expression rate of PTEN was obviously lower in study group than contrast group( P<0. 05 ). Lymph node metastasis of VEGF-C and positive expression of PTEN and TNM in patients with different clinical staging of carcinoma had significant difference(P<0. 05). Conclusions The correlation between the expression and has formed the papillary thyroid carcinoma with VEGF-C and PTEN,it was detected in favor of clinical diagnosis and treatment and prog-nosis of patients,and has important significance.
