背景 近年来研究表明,单核细胞趋化蛋白1(MCP-1)基因多态性与葡萄膜炎易感性密切相关,然而目前国内外关于MCP-1基因-2518A/G多态性与葡萄膜炎发病风险的相关性尚未有一致结论.目的 系统评价MCP-1基因-2518 A/G多态性与葡萄膜炎易感性的关系.方法 按照检索策略,计算机检索PubMed、Embase、Web of Science、中国知网(CNKI)、维普网(VIP)、万方数据及中国生物医学文献数据库(CBD),检索时限为建库起至2014年3月,收集关于MCP-1基因-2518A/G多态性与葡萄膜炎发病风险的相关文献,按照纳入及排除标准筛选文献、提取数据资料,并对纳入研究的文献进行质量评价.采用RevMan 5.2及Stata12.0软件进行Meta分析,计算合并效应量优势比(OR)值及其95％可信区间(CI),并进行发表偏倚及敏感性分析.结果 共纳入8篇研究文献,累积病例1 197例,对照1 570例.MCP-1基因-2518A/G G和A、GG和AA及GG和AG+AA基因型与总体葡萄膜炎发病风险均无明显相关性(均P＞0.05),GG+AG和AA基因型与总体葡萄膜炎发病风险具有显著相关性(P=0.01,OR=1.25,95％C1:1.06～1.48),而敏感性分析结果显示二者无明显相关性(P=0.19,OR=1.16,95％ CI:0.93～1.45).按葡萄膜炎类型进行亚组分析结果显示,携带等位基因G、GG基因型的个体罹患前葡萄膜炎的风险明显增高(G和A:P=0.01,OR=1.49,95％CI:1.16 ～1.90;GG和AA:P=0.01,OR=2.09,95％CI:1.21～3.61;GG+AG和AA:P=0.01,OR=1.58,95％ CI:1.12～2.23;GG和AG+AA:P=0.01,OR=1.78,95％CI:1.12 ～2.83),且GG+AG和AA基因型个体罹患白塞病的风险也明显增高(P=0.04,OR=1.35,95％CI:1.01～1.79),而与其他类型葡萄膜炎发病风险无明显相关(P＞0.05).按种族进行亚组分析结果显示,在黄种人群中,携带等位基因G、GG基因型的个体罹患葡萄膜炎的风险明显增高(G和A:P=0.04,OR=1.15,95％CI:1.01～1.32;GG和AA:P=0.04,OR=1.32,95％ CI:1.02 ～1.71;GG+AG和AA:P=0.01,OR=1.36,95％CI:1.09～1.70),而在白种人群中等位基因G、GG基因型与葡萄膜炎均无明显相关(均P＞0.05).结论 MCP-1基因-2518A/G多态性与白塞病、前葡萄膜炎及黄种人群葡萄膜炎易感性有关,GG基因型及等位基因G可能是白塞病、前葡萄膜炎及黄种人群葡萄膜炎易感的危险因素.
揹景 近年來研究錶明,單覈細胞趨化蛋白1(MCP-1)基因多態性與葡萄膜炎易感性密切相關,然而目前國內外關于MCP-1基因-2518A/G多態性與葡萄膜炎髮病風險的相關性尚未有一緻結論.目的 繫統評價MCP-1基因-2518 A/G多態性與葡萄膜炎易感性的關繫.方法 按照檢索策略,計算機檢索PubMed、Embase、Web of Science、中國知網(CNKI)、維普網(VIP)、萬方數據及中國生物醫學文獻數據庫(CBD),檢索時限為建庫起至2014年3月,收集關于MCP-1基因-2518A/G多態性與葡萄膜炎髮病風險的相關文獻,按照納入及排除標準篩選文獻、提取數據資料,併對納入研究的文獻進行質量評價.採用RevMan 5.2及Stata12.0軟件進行Meta分析,計算閤併效應量優勢比(OR)值及其95％可信區間(CI),併進行髮錶偏倚及敏感性分析.結果 共納入8篇研究文獻,纍積病例1 197例,對照1 570例.MCP-1基因-2518A/G G和A、GG和AA及GG和AG+AA基因型與總體葡萄膜炎髮病風險均無明顯相關性(均P＞0.05),GG+AG和AA基因型與總體葡萄膜炎髮病風險具有顯著相關性(P=0.01,OR=1.25,95％C1:1.06～1.48),而敏感性分析結果顯示二者無明顯相關性(P=0.19,OR=1.16,95％ CI:0.93～1.45).按葡萄膜炎類型進行亞組分析結果顯示,攜帶等位基因G、GG基因型的箇體罹患前葡萄膜炎的風險明顯增高(G和A:P=0.01,OR=1.49,95％CI:1.16 ～1.90;GG和AA:P=0.01,OR=2.09,95％CI:1.21～3.61;GG+AG和AA:P=0.01,OR=1.58,95％ CI:1.12～2.23;GG和AG+AA:P=0.01,OR=1.78,95％CI:1.12 ～2.83),且GG+AG和AA基因型箇體罹患白塞病的風險也明顯增高(P=0.04,OR=1.35,95％CI:1.01～1.79),而與其他類型葡萄膜炎髮病風險無明顯相關(P＞0.05).按種族進行亞組分析結果顯示,在黃種人群中,攜帶等位基因G、GG基因型的箇體罹患葡萄膜炎的風險明顯增高(G和A:P=0.04,OR=1.15,95％CI:1.01～1.32;GG和AA:P=0.04,OR=1.32,95％ CI:1.02 ～1.71;GG+AG和AA:P=0.01,OR=1.36,95％CI:1.09～1.70),而在白種人群中等位基因G、GG基因型與葡萄膜炎均無明顯相關(均P＞0.05).結論 MCP-1基因-2518A/G多態性與白塞病、前葡萄膜炎及黃種人群葡萄膜炎易感性有關,GG基因型及等位基因G可能是白塞病、前葡萄膜炎及黃種人群葡萄膜炎易感的危險因素.
배경 근년래연구표명,단핵세포추화단백1(MCP-1)기인다태성여포도막염역감성밀절상관,연이목전국내외관우MCP-1기인-2518A/G다태성여포도막염발병풍험적상관성상미유일치결론.목적 계통평개MCP-1기인-2518 A/G다태성여포도막염역감성적관계.방법 안조검색책략,계산궤검색PubMed、Embase、Web of Science、중국지망(CNKI)、유보망(VIP)、만방수거급중국생물의학문헌수거고(CBD),검색시한위건고기지2014년3월,수집관우MCP-1기인-2518A/G다태성여포도막염발병풍험적상관문헌,안조납입급배제표준사선문헌、제취수거자료,병대납입연구적문헌진행질량평개.채용RevMan 5.2급Stata12.0연건진행Meta분석,계산합병효응량우세비(OR)치급기95％가신구간(CI),병진행발표편의급민감성분석.결과 공납입8편연구문헌,루적병례1 197례,대조1 570례.MCP-1기인-2518A/G G화A、GG화AA급GG화AG+AA기인형여총체포도막염발병풍험균무명현상관성(균P＞0.05),GG+AG화AA기인형여총체포도막염발병풍험구유현저상관성(P=0.01,OR=1.25,95％C1:1.06～1.48),이민감성분석결과현시이자무명현상관성(P=0.19,OR=1.16,95％ CI:0.93～1.45).안포도막염류형진행아조분석결과현시,휴대등위기인G、GG기인형적개체리환전포도막염적풍험명현증고(G화A:P=0.01,OR=1.49,95％CI:1.16 ～1.90;GG화AA:P=0.01,OR=2.09,95％CI:1.21～3.61;GG+AG화AA:P=0.01,OR=1.58,95％ CI:1.12～2.23;GG화AG+AA:P=0.01,OR=1.78,95％CI:1.12 ～2.83),차GG+AG화AA기인형개체리환백새병적풍험야명현증고(P=0.04,OR=1.35,95％CI:1.01～1.79),이여기타류형포도막염발병풍험무명현상관(P＞0.05).안충족진행아조분석결과현시,재황충인군중,휴대등위기인G、GG기인형적개체리환포도막염적풍험명현증고(G화A:P=0.04,OR=1.15,95％CI:1.01～1.32;GG화AA:P=0.04,OR=1.32,95％ CI:1.02 ～1.71;GG+AG화AA:P=0.01,OR=1.36,95％CI:1.09～1.70),이재백충인군중등위기인G、GG기인형여포도막염균무명현상관(균P＞0.05).결론 MCP-1기인-2518A/G다태성여백새병、전포도막염급황충인군포도막염역감성유관,GG기인형급등위기인G가능시백새병、전포도막염급황충인군포도막염역감적위험인소.
Background Monocyte chemoattractant protein-1 (MCP-1) polymorphisms are demonstrated to be significantly associated with the susceptibility to uveitis in recent years,while a consistent conclusion for the association of MCP-1-2518A/G polymorphism and uveitis risk is not reached yet.Objective This study was to comprehensively investigate the correlation between MCP-1-2518A/G polymorphism and uveitis susceptibility.Methods General searches of electronic database including PubMed,Embase,Web of Science,CNKI,VIP,Wanfang database and China biomedical literature database (CBD) were performed to retrieve published case-control studies regarding the association between MCP-1-2518A/G polymorphism and uveitis risk.The data were screened according to the inclusion and exclusion criteria and extracted,and the quality of included studies was evaluated.The pooled odds ratios (OR) with 95％ confidence intervals (CI) were calculated.Publication bias and sensitivity analysis were also assessed.All statistical analyses were conducted with RevMan 5.2 and Stata 12.0 software.Results A total of 8 eligible case-control studies involving 1 197 cases and 1 570 controls were included in the Meta-analysis.The results showed no significant association of MCP-1-2518A/G polymorphism with uveitis susceptibility in the G vs.A,GG vs.AA and GG vs.AG+AA models (all at P＞0.05).MCP-1-2518A/G polymorphism was found to be significantly associated with uveitis risk in the GG+AG vs.AA model (P =0.01,OR =1.25,95％ CI:1.06-1.48),while no significant association was found by the sensitive analysis (GG + AG vs.AA:P =0.19,OR =1.16,95％ CI:0.93-1.45).The subgroup analysis by uveitis types revealed that the individuals carrying allele-G or GG genotype harbored a significantly increased risk for anterior uveitis (G vs.A:P=0.01,OR=1.49,95％ CI:1.16-1.90;GG vs.AA:P=0.01,OR=2.09,95％ CI:1.21-3.61;GG+AG vs.AA:P=0.01,OR=1.58,95％ CI:1.12-2.23;GG vs.AG+AA:P=0.01,OR=1.78,95％ CI:1.12-2.83).The individuals with GG+AG vs.AA genotype harbored a significantly increased risk for Behcet's disease (BD) (P=0.04,OR =1.35,95％ CI:1.01-1.79) but not for other types of uveitis (P ＞ 0.05).Additionally,a significantly elevated risk was found in uveitis patients with allele-G or GG genotype in Asian population in the subgroup analysis based on ethnicity (G vs.A:P =0.04,OR =1.15,95％ CI:1.01-1.32;GG vs.AA:P=0.04,OR=1.32,95％ CI:1.02-1.71;GG+AG vs.AA:P=0.01,OR =1.36,95％ CI:1.09-1.70),but that was not found in Caucasians population (all at P＞0.05).Conclusions MCP-1-2518A/G polymorphism is significantly associated with the risk of uveitis in Asian population,anterior uveitis and BD.The allele-G or GG genotype may increase the risk of uveitis in Asian population,anterior uveitis and BD.
