国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
13期
961-963
,共3页
赵静渝%陈吉杰%李海燕%魏春华
趙靜渝%陳吉傑%李海燕%魏春華
조정투%진길걸%리해연%위춘화
难治性哮喘%同型半胱氨酸%甲状腺激素
難治性哮喘%同型半胱氨痠%甲狀腺激素
난치성효천%동형반광안산%갑상선격소
Difficult-to-treat asthma%Homocysteine%Thyroid hormones
目的 研究难治性哮喘患者血浆甲状腺激素和同型半胱氨酸(Hcy)水平,探讨其在难治性哮喘中的表达改变及相互关系.方法 采集27例难治性哮喘患者、46例普通哮喘患者和30例健康对照组血浆标本,采用电化学发光法测定血浆甲状腺激素水平,采用反相高效液相色谱荧光检测法测定Hcy水平,并进行相关性分析.结果 难治性哮喘患者组血浆三碘甲状腺原氨酸(TT3)(1.22±0.27)nmol/L、游离三碘甲状腺原氨酸(FT3) (2.26±0.66) pmol/L、游离甲状腺素(FT4)(9.87±2.75) pmol/L水平明显低于普通哮喘患者组(P ＜0.01,P＜0.01,P＜0.05)和健康对照组(P值均＜0.01),普通哮喘患者组血清TT3、FT3水平均低于健康对照组(P值均＜0.05),难治性哮喘患者组、普通哮喘患者组、健康对照组各组间TT4、TSH水平差异无统计学意义.难治性哮喘患者组血浆Hcy水平(19.34±7.24) μmol/L明显高于普通哮喘组(P＜0.05)及健康对照组(P＜0.01),普通哮喘患者组Hcy水平(14.25±4.76) μmol/L和健康对照组(12.56±5.23) μmol/L相比差异无统计学意义.相关分析表明,难治性哮喘患者Hcy水平分别与TT3、FT3水平呈负相关(r=-0.334,P＜0.05;r=-0.403,P＜0.05).结论 难治性哮喘患者血浆甲状腺激素及Hcy水平改变,两者可能相互作用,共同参与影响难治性哮喘患者疾病进展.
目的 研究難治性哮喘患者血漿甲狀腺激素和同型半胱氨痠(Hcy)水平,探討其在難治性哮喘中的錶達改變及相互關繫.方法 採集27例難治性哮喘患者、46例普通哮喘患者和30例健康對照組血漿標本,採用電化學髮光法測定血漿甲狀腺激素水平,採用反相高效液相色譜熒光檢測法測定Hcy水平,併進行相關性分析.結果 難治性哮喘患者組血漿三碘甲狀腺原氨痠(TT3)(1.22±0.27)nmol/L、遊離三碘甲狀腺原氨痠(FT3) (2.26±0.66) pmol/L、遊離甲狀腺素(FT4)(9.87±2.75) pmol/L水平明顯低于普通哮喘患者組(P ＜0.01,P＜0.01,P＜0.05)和健康對照組(P值均＜0.01),普通哮喘患者組血清TT3、FT3水平均低于健康對照組(P值均＜0.05),難治性哮喘患者組、普通哮喘患者組、健康對照組各組間TT4、TSH水平差異無統計學意義.難治性哮喘患者組血漿Hcy水平(19.34±7.24) μmol/L明顯高于普通哮喘組(P＜0.05)及健康對照組(P＜0.01),普通哮喘患者組Hcy水平(14.25±4.76) μmol/L和健康對照組(12.56±5.23) μmol/L相比差異無統計學意義.相關分析錶明,難治性哮喘患者Hcy水平分彆與TT3、FT3水平呈負相關(r=-0.334,P＜0.05;r=-0.403,P＜0.05).結論 難治性哮喘患者血漿甲狀腺激素及Hcy水平改變,兩者可能相互作用,共同參與影響難治性哮喘患者疾病進展.
목적 연구난치성효천환자혈장갑상선격소화동형반광안산(Hcy)수평,탐토기재난치성효천중적표체개변급상호관계.방법 채집27례난치성효천환자、46례보통효천환자화30례건강대조조혈장표본,채용전화학발광법측정혈장갑상선격소수평,채용반상고효액상색보형광검측법측정Hcy수평,병진행상관성분석.결과 난치성효천환자조혈장삼전갑상선원안산(TT3)(1.22±0.27)nmol/L、유리삼전갑상선원안산(FT3) (2.26±0.66) pmol/L、유리갑상선소(FT4)(9.87±2.75) pmol/L수평명현저우보통효천환자조(P ＜0.01,P＜0.01,P＜0.05)화건강대조조(P치균＜0.01),보통효천환자조혈청TT3、FT3수평균저우건강대조조(P치균＜0.05),난치성효천환자조、보통효천환자조、건강대조조각조간TT4、TSH수평차이무통계학의의.난치성효천환자조혈장Hcy수평(19.34±7.24) μmol/L명현고우보통효천조(P＜0.05)급건강대조조(P＜0.01),보통효천환자조Hcy수평(14.25±4.76) μmol/L화건강대조조(12.56±5.23) μmol/L상비차이무통계학의의.상관분석표명,난치성효천환자Hcy수평분별여TT3、FT3수평정부상관(r=-0.334,P＜0.05;r=-0.403,P＜0.05).결론 난치성효천환자혈장갑상선격소급Hcy수평개변,량자가능상호작용,공동삼여영향난치성효천환자질병진전.
Objective To investigate the levels and possible levels and associations of thyroid hormones and homocysteine (Hcy) in difficult-to-treat asthma patients.Methods Plasma samples were collected from 27 difficult-to-treat asthma patients,46 asthma patients and 30 healthy controls.The levels of plasma thyroid hormones were detected by electrochemiluminescence immunoassay,the level of Hcy was detected by fluorescence detection method of reversed phase high performance liquid chromatography.Linear correlation analysis was used to analyze the correlationship between them.Results The levels of plasma total triiodothyronine (TT3) (1.22 ± 0.27) nmol/L,free triiodothyronine (FT3) (2.26±0.66) pmol/L and free thyroxine (FT4)(9.87 ±2.75) pmol/L were significantly lower in difficult-to-treat asthma patients compared to asthma patients (P ＜ 0.01,P ＜ 0.01,P ＜ 0.05) and healthy controls(P ＜0.01).The levels of plasma TT3,FT3 were lower in asthma patients compared to healthy controls (P ＜0.05).No significant difference was found of TT4 and TSH in each group.Hcy level (19.34±7.24) μmol/L was higher in difficult-to-treat asthma patients compared to asthma patients (P ＜0.05) and healthy controls (P ＜0.01).However,there was no significant difference of Hcy level between asthma patients (14.25 ± 4.76) μmol/L and healthy controls (12.56 ± 5.23) μmol/L.In addition,the level of Hcy was negatively correlated with TT3 and FT3 levels respectively (r =-0.334,P ＜ 0.05;r =-0.403,P ＜ 0.05).Conclusions Strong associations were found between thyroid hormones and Hcy in difficult-to-treat asthma patients,which participated in the pathogenesis of difficult-to-treat asthma patients.
