国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
13期
984-987
,共4页
孟丹%徐传藩%陈培生%张晓燕
孟丹%徐傳藩%陳培生%張曉燕
맹단%서전번%진배생%장효연
2型糖尿病%阻塞性睡眠呼吸暂停综合征%炎症因子%体质量指数
2型糖尿病%阻塞性睡眠呼吸暫停綜閤徵%炎癥因子%體質量指數
2형당뇨병%조새성수면호흡잠정종합정%염증인자%체질량지수
Type 2 diabetes%Obstructive sleep apnea hypopnea syndrome%Inflammatory factors%Body mass index
目的 通过观察2型糖尿病合并OSAHS患者的炎性因子变化情况,以提高对OSAHS的认识并为其治疗提供实验依据.方法 选取单纯2型糖尿病患者组(A组)46例、合并OSAHS患者组(B组)61例以及健康体检组(C组)20例.计算各组受试者的体质量指数(body mass index,BMI);采用便携式睡眠呼吸检测仪记录患者睡眠情况并计算睡眠呼吸暂停低通气指数(apnea-hypopnea index,AHI);应用酶联免疫法测定血清IL-6、肿瘤坏死因子a(tumor necrosis factor,TNF-α)及可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule 1,sICAM-1)的水平;采用速率散射比浊法测定血清高敏C反应蛋白(high-sensitivity C protein,hs-CRP)含量.结果 A组和B组患者各炎症因子水平和BMI均显著高于C组(P值均＜0.01);B组患者各炎症因子水平和BMI均显著高于A组(P＜0.01或P＜0.05).相关分析显示hs-CRP、sICAM-1及BMI均与并发OSAHS呈独立正相关(P＜o.01或P＜0.05);BMI、TNF-α、sICAM-1和hs-CRP值均与AHI呈独立正相关(P＜0.01或P＜0.05).结论 血清炎症因子水平与糖尿病患者合并OSAHS相关,炎症因子水平增高和BMI是2型糖尿病患者发生OSAHS的危险因素和病情危险因素,应当引起重视.
目的 通過觀察2型糖尿病閤併OSAHS患者的炎性因子變化情況,以提高對OSAHS的認識併為其治療提供實驗依據.方法 選取單純2型糖尿病患者組(A組)46例、閤併OSAHS患者組(B組)61例以及健康體檢組(C組)20例.計算各組受試者的體質量指數(body mass index,BMI);採用便攜式睡眠呼吸檢測儀記錄患者睡眠情況併計算睡眠呼吸暫停低通氣指數(apnea-hypopnea index,AHI);應用酶聯免疫法測定血清IL-6、腫瘤壞死因子a(tumor necrosis factor,TNF-α)及可溶性細胞間黏附分子-1(soluble intercellular adhesion molecule 1,sICAM-1)的水平;採用速率散射比濁法測定血清高敏C反應蛋白(high-sensitivity C protein,hs-CRP)含量.結果 A組和B組患者各炎癥因子水平和BMI均顯著高于C組(P值均＜0.01);B組患者各炎癥因子水平和BMI均顯著高于A組(P＜0.01或P＜0.05).相關分析顯示hs-CRP、sICAM-1及BMI均與併髮OSAHS呈獨立正相關(P＜o.01或P＜0.05);BMI、TNF-α、sICAM-1和hs-CRP值均與AHI呈獨立正相關(P＜0.01或P＜0.05).結論 血清炎癥因子水平與糖尿病患者閤併OSAHS相關,炎癥因子水平增高和BMI是2型糖尿病患者髮生OSAHS的危險因素和病情危險因素,應噹引起重視.
목적 통과관찰2형당뇨병합병OSAHS환자적염성인자변화정황,이제고대OSAHS적인식병위기치료제공실험의거.방법 선취단순2형당뇨병환자조(A조)46례、합병OSAHS환자조(B조)61례이급건강체검조(C조)20례.계산각조수시자적체질량지수(body mass index,BMI);채용편휴식수면호흡검측의기록환자수면정황병계산수면호흡잠정저통기지수(apnea-hypopnea index,AHI);응용매련면역법측정혈청IL-6、종류배사인자a(tumor necrosis factor,TNF-α)급가용성세포간점부분자-1(soluble intercellular adhesion molecule 1,sICAM-1)적수평;채용속솔산사비탁법측정혈청고민C반응단백(high-sensitivity C protein,hs-CRP)함량.결과 A조화B조환자각염증인자수평화BMI균현저고우C조(P치균＜0.01);B조환자각염증인자수평화BMI균현저고우A조(P＜0.01혹P＜0.05).상관분석현시hs-CRP、sICAM-1급BMI균여병발OSAHS정독립정상관(P＜o.01혹P＜0.05);BMI、TNF-α、sICAM-1화hs-CRP치균여AHI정독립정상관(P＜0.01혹P＜0.05).결론 혈청염증인자수평여당뇨병환자합병OSAHS상관,염증인자수평증고화BMI시2형당뇨병환자발생OSAHS적위험인소화병정위험인소,응당인기중시.
Objective To analyze the inflammatory factors level in type 2 diabetic patients complicated with obstructive sleep apnea syndrome.Methods A total of 46 type 2 simple diabetes patients were set as group A,61 type 2 diabetic patients complicated with obstructive sleep apnea syndrome were set as group B,and 20 health controls were set as group C.Body mass index (BMI) was calculated.Apnea-hypopnea index (AHI) was monitored by portable sleep apnea detector.Interleukin-6 (IL-6),tumor necrosis factor α (TNF-α) and soluble intercellular adhesion molecule 1 (sICAM-1) in serum were tested by enzyme-linked immunosorbent assay.High-sensitivity C protein in serum was tested by rate nephelometry.Results All the inflammatory factors and BMI in group A and group B were all significantly higher than those in group C (all P ＜ 0.01).There was a significant difference of all the indexes between group A and group B (P ＜0.01 or P ＜0.05).BMI,hsCRP and sICAM-1 were independently and positively correlated with patients' OSAHS risk (P ＜ 0.01 or P ＜ 0.05).BMI,TNF-α,hsCRP and sICAM-1 were independently and positively correlated with patients' AHI.Conclusions The inflammatory factors in type 2 diabetic patients are positively correlated with OSAHS risk and AHI,which makes them worth to be paid attention to.
