中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2015年
8期
488-492
,共5页
王丹丹%冯一帆%廉恒丽%赵云娥
王丹丹%馮一帆%廉恆麗%趙雲娥
왕단단%풍일범%렴항려%조운아
非甾体类抗炎药%黄斑厚度%黄斑囊样水肿%白内障微切口超声乳化手术%体层摄影术,光学相干
非甾體類抗炎藥%黃斑厚度%黃斑囊樣水腫%白內障微切口超聲乳化手術%體層攝影術,光學相榦
비치체류항염약%황반후도%황반낭양수종%백내장미절구초성유화수술%체층섭영술,광학상간
Non-steroidal anti-inflammatory drugs%Macular thickness%Cystoid macular edema%Micro-incision phacoemulsification%Tomography,optical coherence
目的 应用频域光学相干断层扫描仪(OCT)观察非甾体类抗炎药(NSAIDs)不同给药方式对微切口白内障超声乳化吸除术后黄斑区厚度的影响.方法 前瞻性随机病例对照研究.将拟行微切口白内障超声乳化手术的患者129例(129眼)按随机数字表法分为甲组(41例),乙组(44例),丙组(44例).甲组术后不使用任何NSAIDs,乙组术后使用普拉洛芬滴跟液,丙组术后使用普拉洛芬滴跟液联合口服布洛芬缓释胶囊.3组患者均于术后当日开始使用妥布霉素地塞米松滴眼液.分别在术前、术后1d、术后1周、术后6周采用OCT观察患者黄斑区图像特征,应用黄斑地形图分析软件测量黄斑区9个分区视网膜平均厚度.采用单因素方差分析、重复测量方差分析及Pearson相关性分析对数据进行处理.结果 3组患者术后BCVA较术前有较大提高,但与黄斑区视网膜厚度的变化不相关.3组患者术后1d时黄斑视网膜厚度差异无统计学意义.3组患者术后1周时黄斑中央区1 mm视网膜厚度差异仍无统计学意义,但是A2区丙组增厚较甲组少,差异有统计学意义(P＜0.05);术后6周时,甲组黄斑CSF厚度明显高于其他2组(P＜0.05);甲组旁中心凹部分区域较乙组、丙组厚,差异有统计学意义.结论 NSAIDs的应用可以减轻微切口白内障超声乳化术后黄斑区视网膜厚度的增加,口服NSAIDs在早期一定程度上减轻了黄斑旁中心凹区视网膜的增厚.
目的 應用頻域光學相榦斷層掃描儀(OCT)觀察非甾體類抗炎藥(NSAIDs)不同給藥方式對微切口白內障超聲乳化吸除術後黃斑區厚度的影響.方法 前瞻性隨機病例對照研究.將擬行微切口白內障超聲乳化手術的患者129例(129眼)按隨機數字錶法分為甲組(41例),乙組(44例),丙組(44例).甲組術後不使用任何NSAIDs,乙組術後使用普拉洛芬滴跟液,丙組術後使用普拉洛芬滴跟液聯閤口服佈洛芬緩釋膠囊.3組患者均于術後噹日開始使用妥佈黴素地塞米鬆滴眼液.分彆在術前、術後1d、術後1週、術後6週採用OCT觀察患者黃斑區圖像特徵,應用黃斑地形圖分析軟件測量黃斑區9箇分區視網膜平均厚度.採用單因素方差分析、重複測量方差分析及Pearson相關性分析對數據進行處理.結果 3組患者術後BCVA較術前有較大提高,但與黃斑區視網膜厚度的變化不相關.3組患者術後1d時黃斑視網膜厚度差異無統計學意義.3組患者術後1週時黃斑中央區1 mm視網膜厚度差異仍無統計學意義,但是A2區丙組增厚較甲組少,差異有統計學意義(P＜0.05);術後6週時,甲組黃斑CSF厚度明顯高于其他2組(P＜0.05);甲組徬中心凹部分區域較乙組、丙組厚,差異有統計學意義.結論 NSAIDs的應用可以減輕微切口白內障超聲乳化術後黃斑區視網膜厚度的增加,口服NSAIDs在早期一定程度上減輕瞭黃斑徬中心凹區視網膜的增厚.
목적 응용빈역광학상간단층소묘의(OCT)관찰비치체류항염약(NSAIDs)불동급약방식대미절구백내장초성유화흡제술후황반구후도적영향.방법 전첨성수궤병례대조연구.장의행미절구백내장초성유화수술적환자129례(129안)안수궤수자표법분위갑조(41례),을조(44례),병조(44례).갑조술후불사용임하NSAIDs,을조술후사용보랍락분적근액,병조술후사용보랍락분적근액연합구복포락분완석효낭.3조환자균우술후당일개시사용타포매소지새미송적안액.분별재술전、술후1d、술후1주、술후6주채용OCT관찰환자황반구도상특정,응용황반지형도분석연건측량황반구9개분구시망막평균후도.채용단인소방차분석、중복측량방차분석급Pearson상관성분석대수거진행처리.결과 3조환자술후BCVA교술전유교대제고,단여황반구시망막후도적변화불상관.3조환자술후1d시황반시망막후도차이무통계학의의.3조환자술후1주시황반중앙구1 mm시망막후도차이잉무통계학의의,단시A2구병조증후교갑조소,차이유통계학의의(P＜0.05);술후6주시,갑조황반CSF후도명현고우기타2조(P＜0.05);갑조방중심요부분구역교을조、병조후,차이유통계학의의.결론 NSAIDs적응용가이감경미절구백내장초성유화술후황반구시망막후도적증가,구복NSAIDs재조기일정정도상감경료황반방중심요구시망막적증후.
Objective To compare the effects of different delivery methods of non-steroidal anti-inflammatory drugs (NSAIDs) on changes in macular thickness after uncompIicated micro-incision phacoemulsification using spectral domain optical coherence tomography (OCT).Methods In this prospective study,129 patients were randomly divided into three groups.After surgery,group A (41 cases) received no NSAIDs,group B (44 cases) received pranoprofen and group C (44 cases) received pranoprofen combined with ibuprofen (sustained-release capsules).All patients were treated with topical tobramycin and dexamethasone postoperatively.OCT measurements were performed preoperatively and at 1 day,1 week and 6 weeks postoperatively.The mean macular thicknesses of 9 sectors were analyzed with the macular thickness mapping protocol of the OCT.Data were analyzed using one-way ANOVA,repeate measured ANOVA,and Pearson correlation analysis.Results Compared with preoperative acuity,there was a significant increase in best corrected visual acuity (BCVA) after surgery in all 3 groups.However,there was no correlation between changes in macular thickness and BCVA.At 1 day after surgery,no significant differences in retinal thickness were found among the 3 groups.At 1 week after surgery,the 1-mm central subfield (CSF) thickness showed no significant difference among the groups.However,there was a significant difference in the retinal thickness of the parafoveal area (A2) between groups A and C (P＜0.05).Furthermore,the thicknesses of the CSF and some parafoveal areas in group A were significantly greater than those in groups B and C (P＜0.05).Conclusion NSAIDs may have some effects on alleviating macular thickening after surgery.To some extent,oral NSAIDs are effective during the early stage after surgery.
