实用疼痛学杂志
實用疼痛學雜誌
실용동통학잡지
PAIN CLINIC JOURNAL
2015年
1期
60-65
,共6页
李珺%石翊飒%盛晓赟%周海娇
李珺%石翊颯%盛曉赟%週海嬌
리군%석익삽%성효빈%주해교
丙戊茶碱%神经病理性疼痛%预先镇痛
丙戊茶堿%神經病理性疼痛%預先鎮痛
병무다감%신경병이성동통%예선진통
Propentofylline%Neuropathic pain%Preemptive analgesia
丙戊茶碱是甲基黄嘌呤的衍生物,近年来随着对其研究的深入,发现它是胶质细胞的调节剂,对胶质细胞的激活和前炎性细胞因子释放有抑制作用,从而达到对神经病理性疼痛的镇痛.本文将从丙戊茶碱的分子结构、药理作用以及疼痛治疗的研究现状等方面作一综述.
丙戊茶堿是甲基黃嘌呤的衍生物,近年來隨著對其研究的深入,髮現它是膠質細胞的調節劑,對膠質細胞的激活和前炎性細胞因子釋放有抑製作用,從而達到對神經病理性疼痛的鎮痛.本文將從丙戊茶堿的分子結構、藥理作用以及疼痛治療的研究現狀等方麵作一綜述.
병무다감시갑기황표령적연생물,근년래수착대기연구적심입,발현타시효질세포적조절제,대효질세포적격활화전염성세포인자석방유억제작용,종이체도대신경병이성동통적진통.본문장종병무다감적분자결구、약리작용이급동통치료적연구현상등방면작일종술.
Propentofylline is a methylxanthine derivative.In recent years,it was found that propentofylline was a regulator of glial cells with the deepening of its research.Propentofylline can cause an inhibition of glial cell activation and proinflammatory cytokine release,so as to achieve analgesia for neuropathic pain.This article will review propentofylline in molecular structure,pharmacological effects,clinical application and other aspects in pain management.
