CAJ | 학술논문

支气管哮喘(简称哮喘)是一种气道慢性炎症性疾病,在哮喘的发病机制中,表观遗传学是联系环境因素与遗传易感因素之间的纽带,导致机体免疫系统的发育及功能紊乱,从而促进哮喘的发生.DNA甲基化作为最常见的表观遗传修饰形式,食物与环境因素通过DNA甲基化产生对哮喘细胞学组分CD4+T细胞分化的影响.母体产前食用富含甲基供体饮食,吸入环境中的危险因子均可影响CD4+T细胞在体内的DNA甲基化,导致“Th2极化”,促进哮喘的发生.
지기관효천(간칭효천)시일충기도만성염증성질병,재효천적발병궤제중,표관유전학시련계배경인소여유전역감인소지간적뉴대,도치궤체면역계통적발육급공능문란,종이촉진효천적발생.DNA갑기화작위최상견적표관유전수식형식,식물여배경인소통과DNA갑기화산생대효천세포학조분CD4+T세포분화적영향.모체산전식용부함갑기공체음식,흡입배경중적위험인자균가영향CD4+T세포재체내적DNA갑기화,도치“Th2겁화”,촉진효천적발생.
Bronchial asthma (asthma) is a chronic inflammatory disease of the airways.In the pathogenesis of asthma,epigenetics links the environmental factors and genetic susceptibility,interrupting the differentiation and function of the immune system,thus contributing to the occurrence of asthma.DNA methylation is known as the most common form of epigenetics.Food and environmental factors affect the differentiation of CD4+ T cells among the cellular components of asthma by DNA methylation.Maternal prenatal consumption of diet rich in methyl donors,and inhalation of risk factors in the environment can affect DNA methylation in CD4+ T cells in vivo,resulting in "Th2 polarization" and promoting the disease of asthma.