中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2015年
4期
225-230
,共6页
曾宪鹏%叶啟发%王彦峰%李玲%熊艳%钟自彪%范晓礼%刘忠忠%李宁
曾憲鵬%葉啟髮%王彥峰%李玲%熊豔%鐘自彪%範曉禮%劉忠忠%李寧
증헌붕%협계발%왕언봉%리령%웅염%종자표%범효례%류충충%리저
肾移植%器官保存%低温保存
腎移植%器官保存%低溫保存
신이식%기관보존%저온보존
Kidney transplantion%Organ preservation%Cryopreservation
目的 探讨低温机械灌注与冷保存应用于心脏死亡器官捐赠(DCD)供肾的效果差异,为临床DCD供肾选取最佳保存方式提供依据.方法 计算机检索中国知网、中国生物医学文献、维普中文科技期刊、万方数据知识服务平台、PubMed、EMbase、Ovid、EBSCO数据库,检索时间均为2000年1月至2014年12月,同时检索相关文献的参考文献,纳入所有低温机械灌注与冷保存在DCD供肾效果分析的随机对照试验、病例对照试验及回顾性队列分析,应用Review Manager软件对资料进行荟萃分析.结果 10篇文献纳入荟萃分析,低温机械灌注组1 590例,冷保存组1 834例.低温机械灌注组的受者移植肾功能延迟恢复发生率低(比值比=0.49,95％可信区间为0.30～0.80,P=0.004).两组原发性肾脏无功能发生率的差异无统计学意义(比值比=1.55,95％可信区间为0.54～4.42,P=0.41)且移植后1年移植肾存活率的差异也无统计学意义(比值比=0.79,95％可信区间为0.37～1.69,P=0.54).结论 在DCD供肾移植中,低温机械灌注的保存方式优于冷保存,但其改善保存效果的能力有限.
目的 探討低溫機械灌註與冷保存應用于心髒死亡器官捐贈(DCD)供腎的效果差異,為臨床DCD供腎選取最佳保存方式提供依據.方法 計算機檢索中國知網、中國生物醫學文獻、維普中文科技期刊、萬方數據知識服務平檯、PubMed、EMbase、Ovid、EBSCO數據庫,檢索時間均為2000年1月至2014年12月,同時檢索相關文獻的參攷文獻,納入所有低溫機械灌註與冷保存在DCD供腎效果分析的隨機對照試驗、病例對照試驗及迴顧性隊列分析,應用Review Manager軟件對資料進行薈萃分析.結果 10篇文獻納入薈萃分析,低溫機械灌註組1 590例,冷保存組1 834例.低溫機械灌註組的受者移植腎功能延遲恢複髮生率低(比值比=0.49,95％可信區間為0.30～0.80,P=0.004).兩組原髮性腎髒無功能髮生率的差異無統計學意義(比值比=1.55,95％可信區間為0.54～4.42,P=0.41)且移植後1年移植腎存活率的差異也無統計學意義(比值比=0.79,95％可信區間為0.37～1.69,P=0.54).結論 在DCD供腎移植中,低溫機械灌註的保存方式優于冷保存,但其改善保存效果的能力有限.
목적 탐토저온궤계관주여랭보존응용우심장사망기관연증(DCD)공신적효과차이,위림상DCD공신선취최가보존방식제공의거.방법 계산궤검색중국지망、중국생물의학문헌、유보중문과기기간、만방수거지식복무평태、PubMed、EMbase、Ovid、EBSCO수거고,검색시간균위2000년1월지2014년12월,동시검색상관문헌적삼고문헌,납입소유저온궤계관주여랭보존재DCD공신효과분석적수궤대조시험、병례대조시험급회고성대렬분석,응용Review Manager연건대자료진행회췌분석.결과 10편문헌납입회췌분석,저온궤계관주조1 590례,랭보존조1 834례.저온궤계관주조적수자이식신공능연지회복발생솔저(비치비=0.49,95％가신구간위0.30～0.80,P=0.004).량조원발성신장무공능발생솔적차이무통계학의의(비치비=1.55,95％가신구간위0.54～4.42,P=0.41)차이식후1년이식신존활솔적차이야무통계학의의(비치비=0.79,95％가신구간위0.37～1.69,P=0.54).결론 재DCD공신이식중,저온궤계관주적보존방식우우랭보존,단기개선보존효과적능력유한.
Objective To compare the effect of hypothermic machine perfusion (HMP) vs.cold storage (CS) in kidney transplantation from donation after cardiac death,so as to provide the basis for clinical application.Method Such databases as CNKI,CBMdisc,VIP,Wanfang,PubMed,EMbase,Ovid and EBSCO were searched from January 2000 to December 2014 for collecting the randomized controlled trials (RCTs),case control studies and cohort analysis about the outcomes in patients receiving DCD kidneys preserved by HMP or by CS preservation.At the same time,the relevant literature references were also retrieved.The meta-analysis was conducted by using Review Manager5.3 software.Result Ten publications,involving 1590 HMP and 1834 CS preserved DCD kidney transplant recipients,were included.HMP preserved DCD kidney transplant recipients had a decreased incidence of delayed graft function (DGF) (OR =0.49,95％ CI 0.30-0.80,P =0.004) compared to CS.However,there were no significant differences between the two technologies in incidence of primary non-function (OR =1.55,95％ CI 0.54-4.42,P =0.41) and one-year graft survival (OR =0.79,95％ CI 0.37-1.69,P =0.54).Conclusion In kidney transplantion from donation after cardiac death,HMP preservation is superior to CS,but the improving effect of preservation is limited.
