国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2015年
8期
699-702
,共4页
陈彦芳%安伟华%孙英惠%赵朋英
陳彥芳%安偉華%孫英惠%趙朋英
진언방%안위화%손영혜%조붕영
动脉硬化%心脏病%心绞痛%中草药%舒心活血汤
動脈硬化%心髒病%心絞痛%中草藥%舒心活血湯
동맥경화%심장병%심교통%중초약%서심활혈탕
Arteriosclerosis%Heart diseases%Angina pectoris%Drugs,Chinese herbal%Shuxin-Huoxue decoction
目的：评价自拟舒心活血汤治疗冠心病心绞痛的临床疗效。方法本研究为随机对照研究。将符合纳入标准的86例冠心病心绞痛患者按随机数字法分为2组各43例，对照组采用西医常规治疗，治疗组在对照组基础上加用自拟舒心活血汤治疗。采用循环酶法检测血清同型半胱氨酸(homocysteine, Hcy)，免疫比浊法测定高敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)；彩色多普勒超声诊断仪测定左心室射血分数(left ventricular ejection fraction, LVEF)、每搏输出量(stroke volume, SV)、心输出量(cardiac output, CO)、心脏指数(cardiac index, CI)，观察2组治疗前后各指标变化并评价其临床疗效。结果随访后4周，治疗组、对照组总有效率分别为90.7%(39/43)、74.4%(32/43)，2组比较差异有统计学意义(χ2＝3.957，P＝0.047)。随访后4周，治疗组LVEF[(65.7±8.7)%比(61.5±8.4)%，t＝2.277]、SV[(86.9±16.8)ml比(79.2±16.5)ml，t＝2.144]、CO[(49.3±9.1)ml/m2比(44.7±8.8)ml/m2，t＝2.383]、CI[(3.7±0.9)L/min?m2比(3.3±0.7)L/min?m2，t＝2.301]均较对照组明显升高(P＜0.05)。随访后4周，治疗组血清 Hcy[(8.7±3.7)μmol/L比(11.4±3.5)μmol/L，t＝3.476]、hs-CRP[(2.7±1.1)mg/L比(3.5±1.3)mg/L，t＝3.081]水平下降情况优于对照组(P＜0.01)。结论自拟舒心活血汤可改善冠心病心绞痛患者的心脏功能，提高临床疗效。
目的：評價自擬舒心活血湯治療冠心病心絞痛的臨床療效。方法本研究為隨機對照研究。將符閤納入標準的86例冠心病心絞痛患者按隨機數字法分為2組各43例，對照組採用西醫常規治療，治療組在對照組基礎上加用自擬舒心活血湯治療。採用循環酶法檢測血清同型半胱氨痠(homocysteine, Hcy)，免疫比濁法測定高敏C反應蛋白(hypersensitive C-reactive protein, hs-CRP)；綵色多普勒超聲診斷儀測定左心室射血分數(left ventricular ejection fraction, LVEF)、每搏輸齣量(stroke volume, SV)、心輸齣量(cardiac output, CO)、心髒指數(cardiac index, CI)，觀察2組治療前後各指標變化併評價其臨床療效。結果隨訪後4週，治療組、對照組總有效率分彆為90.7%(39/43)、74.4%(32/43)，2組比較差異有統計學意義(χ2＝3.957，P＝0.047)。隨訪後4週，治療組LVEF[(65.7±8.7)%比(61.5±8.4)%，t＝2.277]、SV[(86.9±16.8)ml比(79.2±16.5)ml，t＝2.144]、CO[(49.3±9.1)ml/m2比(44.7±8.8)ml/m2，t＝2.383]、CI[(3.7±0.9)L/min?m2比(3.3±0.7)L/min?m2，t＝2.301]均較對照組明顯升高(P＜0.05)。隨訪後4週，治療組血清 Hcy[(8.7±3.7)μmol/L比(11.4±3.5)μmol/L，t＝3.476]、hs-CRP[(2.7±1.1)mg/L比(3.5±1.3)mg/L，t＝3.081]水平下降情況優于對照組(P＜0.01)。結論自擬舒心活血湯可改善冠心病心絞痛患者的心髒功能，提高臨床療效。
목적：평개자의서심활혈탕치료관심병심교통적림상료효。방법본연구위수궤대조연구。장부합납입표준적86례관심병심교통환자안수궤수자법분위2조각43례，대조조채용서의상규치료，치료조재대조조기출상가용자의서심활혈탕치료。채용순배매법검측혈청동형반광안산(homocysteine, Hcy)，면역비탁법측정고민C반응단백(hypersensitive C-reactive protein, hs-CRP)；채색다보륵초성진단의측정좌심실사혈분수(left ventricular ejection fraction, LVEF)、매박수출량(stroke volume, SV)、심수출량(cardiac output, CO)、심장지수(cardiac index, CI)，관찰2조치료전후각지표변화병평개기림상료효。결과수방후4주，치료조、대조조총유효솔분별위90.7%(39/43)、74.4%(32/43)，2조비교차이유통계학의의(χ2＝3.957，P＝0.047)。수방후4주，치료조LVEF[(65.7±8.7)%비(61.5±8.4)%，t＝2.277]、SV[(86.9±16.8)ml비(79.2±16.5)ml，t＝2.144]、CO[(49.3±9.1)ml/m2비(44.7±8.8)ml/m2，t＝2.383]、CI[(3.7±0.9)L/min?m2비(3.3±0.7)L/min?m2，t＝2.301]균교대조조명현승고(P＜0.05)。수방후4주，치료조혈청 Hcy[(8.7±3.7)μmol/L비(11.4±3.5)μmol/L，t＝3.476]、hs-CRP[(2.7±1.1)mg/L비(3.5±1.3)mg/L，t＝3.081]수평하강정황우우대조조(P＜0.01)。결론자의서심활혈탕가개선관심병심교통환자적심장공능，제고림상료효。
ObjiectiveTo investigate the clinical efficacy of Chinese medicineShuxin-Huoxue decoction on coronary heart disease and angina pectoris.MethodsThis study was a randomized controlled trial. 86 patients with coronary heart disease and angina pectoris and conformed to the indusive criteria were randomly divided into a control group and a treatment group, with 43 cases in each group. The control group was treated with conventional western medicine, the treatment group was treated with traditional Chinese medicineShuxin-Huoxue decoction. Serum homocysteine (Hcy) was measured by enzymatic cycling assay, high sensitive C reactive protein (hs-CRP) was measured by immunotubidimetric assay and left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac output (CO), cardiac index (CI) were measured by color doppler echocardiography before and after treatment. The clinical effect of the two groups was evaluated.ResultsThe total effective rate of the treatment group and the control group was 90.7% (39/43) and 74.4% (32/43) respectively,there was significant difference (χ2=3.957,P=0.047). Followed up for 4 weeks, LVEF(65.7% ± 8.7% vs. 61.5% ± 8.4%,t=2.277), SV(86.9 ± 16.8 ml vs.79.2 ± 16.5 ml,t=2.144), CO(49.3 ± 9.1 ml/m2 vs. 44.7 ± 8.8 ml/m2,t=2.383), CI (3.7 ± 0.9 L/min?m2 vs. 3.3 ± 0.7 L/min?m2,t=2.301) of the treatment group were significantly improved after treatment than those of the control group (P<0.05), and the decrease of serum Hcy (8.7± 3.7mmol/L vs. 11.4± 3.5mmol/L,t=3.476), hs-CRP (2.7± 1.1 mg/L vs. 3.5± 1.3 mg/L,t=3.081) level of the treatment group were better than those of the control group(P<0.01).ConclusionTraditional Chinese medicineShuxin-Huoxue decoction has good therapeutic effect on coronary heart disease and angina pectoris.
