CAJ | 학술논문

目的：对社区癫患者进行随访，获得其长期的死亡风险，并对相关影响因素进行分析。方法对2002年复旦大学附属华山医院和神经病学研究所在上海市金山区吕巷镇调查时确诊的65例癫患者，于2014年(距基线调查时间12年)以面见方式进行随访，由调查者收集资料、填写随访问卷，分析患者的长期预后情况。结果完成调查共计60例，失访5例(失访率7.7%)。共发现死亡病例11/60例，病死率为18.3%(95%CI：10.0~29.6)；肿瘤是首要死因，占全部死因的27.3%。标化死亡比(SMR)为2.6(95%CI：1.4~4.5)，各年龄段中以40~45岁的SMR最高(8.9)。COX比例风险回归模型分析显示部分性癫发作(HR=5.4，95%CI：1.2~24.0)是患者死亡的独立危险因素。结论该社区癫患者的死亡风险是普通人群的2.6倍，肿瘤是首要死因。
목적：대사구전환자진행수방，획득기장기적사망풍험，병대상관영향인소진행분석。방법대2002년복단대학부속화산의원화신경병학연구소재상해시금산구려항진조사시학진적65례전환자，우2014년(거기선조사시간12년)이면견방식진행수방，유조사자수집자료、전사수방문권，분석환자적장기예후정황。결과완성조사공계60례，실방5례(실방솔7.7%)。공발현사망병례11/60례，병사솔위18.3%(95%CI：10.0~29.6)；종류시수요사인，점전부사인적27.3%。표화사망비(SMR)위2.6(95%CI：1.4~4.5)，각년령단중이40~45세적SMR최고(8.9)。COX비례풍험회귀모형분석현시부분성전발작(HR=5.4，95%CI：1.2~24.0)시환자사망적독립위험인소。결론해사구전환자적사망풍험시보통인군적2.6배，종류시수요사인。
Aim To conducted a follow up the people with epilepsy (PWE) diagnosed in the prevalence study in Shanghai Jinshan District 12 years ago to observe the mortality of PWE. Methods A face-to-face interview to follow up the 65 PWE diagnosed in the prevalence study in Jinshan District, Shanghai, 2002 were carried out in 2014. Results 11 death cases were found in the cohort. The case fatality was 18.3%(95%CI 10.0-29.6). Tumor was the most common cause of death in the cohort, accounting for 27.3%of all death. The overall standardized mortality rate (SMR) was 2.56 (95%CI: 1.35-4.45). PWE with 40 to 45 years old suffered the highest SMR among all the age groups. COX regression analysis indicated that partial seizure was an independent risk factor for death (HR 5.40, 95%CI:1.21-24.04) in the present cohort. Conclusion The risk of death among PWE was 2.56 times higher than general population in the present study. Tumor was the most common cause of death in the cohort.