CAJ | 학술논문

目的：：比较喹硫平与氨磺必利治疗女性精神分裂症患者疗效与不良反应。方法：选取女性患者120例,随机分为观察组和对照组,每组各60例。观察组患者给予喹硫平片口服,最大剂量至0.7 g/ d；对照组患者给予口服氨磺必利,最大剂量至1.0 g/ d,两组患者均治疗8周,以阳性和阴性症状量表及精神病理症状量表(PANSS)评定疗效,以不良反应量表(TESS)和实验室监测结果评定其安全性,在治疗前及治疗后2、4、8周末评定疗效及不良反应。结果：两组患者临床疗效相当,差异无统计学意义(P>0.05)；对照组患者发生闭经及体重增加等不良反应大于观察组,差异有统计学意义(P<0.05)。结论：喹硫平与氨磺必利治疗女性精神分裂症患者的疗效相似,氨磺必利的不良反应大于喹硫平。
목적：：비교규류평여안광필리치료녀성정신분렬증환자료효여불량반응。방법：선취녀성환자120례,수궤분위관찰조화대조조,매조각60례。관찰조환자급여규류평편구복,최대제량지0.7 g/ d；대조조환자급여구복안광필리,최대제량지1.0 g/ d,량조환자균치료8주,이양성화음성증상량표급정신병리증상량표(PANSS)평정료효,이불량반응량표(TESS)화실험실감측결과평정기안전성,재치료전급치료후2、4、8주말평정료효급불량반응。결과：량조환자림상료효상당,차이무통계학의의(P>0.05)；대조조환자발생폐경급체중증가등불량반응대우관찰조,차이유통계학의의(P<0.05)。결론：규류평여안광필리치료녀성정신분렬증환자적료효상사,안광필리적불량반응대우규류평。
Objective: To compare clinical efficacy and adverse reactions of Quetiapine and Amisulpride in treatment of female schizophrenia patients. Methods: 120 cases of female patients were randomly assigned to control group (60 cases) and observation group (60 cases). The observation group was treated with Quetiapine tablets for 8 weeks, and the maximum dose was 0. 7g/ d; while the control group was treated with Amisulpride tablets for 8 weeks, and the maximum dose was 1. 0g/ d. The positive and negative syn-drome scale (PANSS) was used to assess the efficacy, while the treatment emergent symptom scale (TESS) and laboratory examina-tions were used to evaluate the adverse reaction at baseline, and 2, 4 and 8 weeks after the treatment. Results: The treatment efficacy was equal between the two groups, and there was no statistical difference (P>0. 05). The control group had significantly more cases of amenorrhea and weight gain than observation group, and the difference was statistically significant (P<0. 05). Conclusions: Quetiap-ine and Amisulpride have equal clinical efficacy in the treatment of female schizophrenia patients; however, Amisulpride has more ad-verse reactions than Quetiapine.