国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2015年
8期
691-694
,共4页
糖尿病神经病变%黄芪桂枝五物汤%氧化性应激
糖尿病神經病變%黃芪桂枝五物湯%氧化性應激
당뇨병신경병변%황기계지오물탕%양화성응격
Diabetic neuropathies%Huang Qi Gui Zhi Wu Wu Tang%Oxidative stress
目的：评价黄芪桂枝五物汤加减治疗糖尿病周围神经病变(diabetic peripheral neuropathy, DPN)的临床疗效。方法纳入78例DNP患者并按随机数字表法分为2组各39例。对照组适当运动、控制饮食并配合降糖药物、甲钴胺和维生素B1；治疗组在此基础上加服黄芪桂枝五物汤，均治疗8周。采用酶比色法检测血清超氧化物歧化酶(superoxide dismutase, SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase, GSH-Px)和过氧化氢酶活性，采用比色法检测血清丙二醛水平；肌电图/诱发电位仪检测感觉神经传导速度(sensory nerve conduction velocity, SCV)和运动神经传导速度(motor nerve conduction velocity, MCV)。结果治疗后，治疗组MCV[(43.12±4.1)m/s比(40.27±2.8)m/s，t＝3.585]、SCV[(41.51±3.4)m/s比(39.63±3.5)m/s，t＝2.406]均较对照组升高(P＜0.05)；SOD[(51.1±6.6)U/ml 比(47.6±3.9)U/ml，t＝2.851]、GSH-Px[(241.7±36.1)U/ml比(213.9±31.7)U/ml，t＝3.614]抗氧化酶活性明显高于对照组(P均＜0.01)。治疗组、对照组总有效率分别为87.2%(34/39)、69.2%(27/39)，2组比较差异有统计学意义(χ2＝4.333， P＝0.033)。结论黄芪桂枝五物汤联合西医常规疗法可改善DNP患者抗氧化能力，控制DNP的发展。
目的：評價黃芪桂枝五物湯加減治療糖尿病週圍神經病變(diabetic peripheral neuropathy, DPN)的臨床療效。方法納入78例DNP患者併按隨機數字錶法分為2組各39例。對照組適噹運動、控製飲食併配閤降糖藥物、甲鈷胺和維生素B1；治療組在此基礎上加服黃芪桂枝五物湯，均治療8週。採用酶比色法檢測血清超氧化物歧化酶(superoxide dismutase, SOD)、穀胱甘肽過氧化物酶(glutathione peroxidase, GSH-Px)和過氧化氫酶活性，採用比色法檢測血清丙二醛水平；肌電圖/誘髮電位儀檢測感覺神經傳導速度(sensory nerve conduction velocity, SCV)和運動神經傳導速度(motor nerve conduction velocity, MCV)。結果治療後，治療組MCV[(43.12±4.1)m/s比(40.27±2.8)m/s，t＝3.585]、SCV[(41.51±3.4)m/s比(39.63±3.5)m/s，t＝2.406]均較對照組升高(P＜0.05)；SOD[(51.1±6.6)U/ml 比(47.6±3.9)U/ml，t＝2.851]、GSH-Px[(241.7±36.1)U/ml比(213.9±31.7)U/ml，t＝3.614]抗氧化酶活性明顯高于對照組(P均＜0.01)。治療組、對照組總有效率分彆為87.2%(34/39)、69.2%(27/39)，2組比較差異有統計學意義(χ2＝4.333， P＝0.033)。結論黃芪桂枝五物湯聯閤西醫常規療法可改善DNP患者抗氧化能力，控製DNP的髮展。
목적：평개황기계지오물탕가감치료당뇨병주위신경병변(diabetic peripheral neuropathy, DPN)적림상료효。방법납입78례DNP환자병안수궤수자표법분위2조각39례。대조조괄당운동、공제음식병배합강당약물、갑고알화유생소B1；치료조재차기출상가복황기계지오물탕，균치료8주。채용매비색법검측혈청초양화물기화매(superoxide dismutase, SOD)、곡광감태과양화물매(glutathione peroxidase, GSH-Px)화과양화경매활성，채용비색법검측혈청병이철수평；기전도/유발전위의검측감각신경전도속도(sensory nerve conduction velocity, SCV)화운동신경전도속도(motor nerve conduction velocity, MCV)。결과치료후，치료조MCV[(43.12±4.1)m/s비(40.27±2.8)m/s，t＝3.585]、SCV[(41.51±3.4)m/s비(39.63±3.5)m/s，t＝2.406]균교대조조승고(P＜0.05)；SOD[(51.1±6.6)U/ml 비(47.6±3.9)U/ml，t＝2.851]、GSH-Px[(241.7±36.1)U/ml비(213.9±31.7)U/ml，t＝3.614]항양화매활성명현고우대조조(P균＜0.01)。치료조、대조조총유효솔분별위87.2%(34/39)、69.2%(27/39)，2조비교차이유통계학의의(χ2＝4.333， P＝0.033)。결론황기계지오물탕연합서의상규요법가개선DNP환자항양화능력，공제DNP적발전。
ObjectiveTo evaluate the therapeutic effect ofHuangqi-Guizhi-Wuwu decoction in patients with diabetic peripheral neuropathy (DPN).MethodsA total of 78 patients with DNP were included and divided into a control group and a treatment group, with 39 in each group. The patients in the control group were administrated with appropriate exercise, control diet, hypoglycemics, mecobalamin and vitamin B1, those in the treatment group were receivedHuangqi-Guizhi-Wuwu decoction on the basis of the control group. The patients in both groups were treated for 8 weeks. The serum activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase were determined by enzymatic-colorimetric method, and the serum malondialdehyde level was measured using colorimetric method. Sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) were measured using an Electromyograph and Evoked Potential Equipment.ResultsAfter treatment, MCV (43.12 ± 4.1 m/svs. 40.27 ± 2.8 m/s;t=3.585,P<0.05)、SCV (41.51 ± 3.4 m/svs. 39.63 ± 3.5 m/s;t=2.406,P<0.05) in the treatment group were significantly increased than those in the control group. The serum activities of SOD (51.1 ± 6.6 U/mlvs. 47.6 ± 3.9 U/ml;t=2.851,P<0.01),GSH-Px (241.7 ± 36.1 U/mlvs. 213.9 ± 31.7 U/ml;t=3.614,P<0.01) in the treatment group were significantly increased than those in the control group. The total efficiency in the treatment group was significantly higher than that in the control group (87.2%vs. 69.2%;χ2=4.333,P=0.033).ConclusionsHuangqi-Guizhi-Wuwu decoction combined with conventional therapy could improve antioxidant capacity and control DPN progress in patients with DPN.
