CAJ | 학술논문

目的：观察2型糖尿病、糖尿病下肢溃疡（DLU）患者血浆丙二醛（MDA）及辅酶 Q10水平的变化。方法DLU 组15例（7男，8女），糖尿病组15例（8男，7女），健康对照组10例，各组性别、年龄差异无统计学意义。实验室检验三组血浆 MDA、CoQ10及糖化血红蛋白水平。结果糖尿病组、DLU 组 MDA 水平[（7．07±3．15）μmol／L、（6．82±2．66）μmol／L]显著高于对照组[（4．28±0．41）μmol／L]（F ＝104．675，P ＜0.01），而 CoQ10水平[（0．33±0．16）mg、（0．31±0．16）mg]明显低于对照组[（0．86±0．13）mg]（F ＝46.709， P ＜0．05）。结论由于血浆中 MDA 水平的升高和 CoQ10水平的降低，证明了2型糖尿病患者在氧化应激方面风险的增加，特别是合并下肢溃疡的患者。
목적：관찰2형당뇨병、당뇨병하지궤양（DLU）환자혈장병이철（MDA）급보매 Q10수평적변화。방법DLU 조15례（7남，8녀），당뇨병조15례（8남，7녀），건강대조조10례，각조성별、년령차이무통계학의의。실험실검험삼조혈장 MDA、CoQ10급당화혈홍단백수평。결과당뇨병조、DLU 조 MDA 수평[（7．07±3．15）μmol／L、（6．82±2．66）μmol／L]현저고우대조조[（4．28±0．41）μmol／L]（F ＝104．675，P ＜0.01），이 CoQ10수평[（0．33±0．16）mg、（0．31±0．16）mg]명현저우대조조[（0．86±0．13）mg]（F ＝46.709， P ＜0．05）。결론유우혈장중 MDA 수평적승고화 CoQ10수평적강저，증명료2형당뇨병환자재양화응격방면풍험적증가，특별시합병하지궤양적환자。
Objective To investigate the level of plasma malondialdehyde (MDA)and coenzyme Q10 (CoQ10)in patients with type 2 diabetes mellitus,diabetic leg ulcer(DLU).Methods The DLU group consisted of 15 patients with leg ulcers and type 2 diabetes mellitus (7 men and 8 women).The diabetes group consisted of 15 patients with type 2 diabetes mellitus (8 men and 7 women).Ten healthy individuals,age and sex matched with the patients,were used as a control group.Laboratory investigations in the form of glycosylated hemoglobin,plasma MDA and plasma CoQ10 were assessed for all patients and controls.Results The study revealed that in the diabetes group,especially in the DLU group,the MDA level [(7.07 ±3.15)μmol/L and (3.15 ±2.66)μmol/L]was signifi-cantly higher than control group [(4.28 ±0.41)μmol/L]and the index difference between them (F =104.675,P <0.01),while CoQ10 levels in the two groups data[(0.33 ±0.16)mg and (0.16 ±0.16)mg ]were significantly lower than the control group [(0.86 ±0.13)mg](F =46.709,P <0.05).Conclusion Type 2 diabetic patients, especially with DLU,are at increased risk of oxidative stress manifested by increased plasma MDA.