中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
23期
5-6,15
,共3页
肿瘤溶解综合征%诊断%治疗
腫瘤溶解綜閤徵%診斷%治療
종류용해종합정%진단%치료
Tumor lysis syndrome%Diagnosis%Treatment
肿瘤溶解综合征(Tumor lysis syndrome，TLS)是血液系统恶性病中较常见的早期严重并发症，也可发生于其他恶性肿瘤。TLS是由于肿瘤细胞短期内大量溶解，释放细胞内代谢产物，引起代谢紊乱的一组综合征，临床特点为高尿酸血症、高血钾、高血磷、低血钙、急性肾功能衰竭。积极预防、早期诊断和有效的治疗可避免严重并发症的发生。本文复习相关文献以探讨TLS发生的病理机制、流行病学特征、高危因素、临床诊断、预防及治疗。
腫瘤溶解綜閤徵(Tumor lysis syndrome，TLS)是血液繫統噁性病中較常見的早期嚴重併髮癥，也可髮生于其他噁性腫瘤。TLS是由于腫瘤細胞短期內大量溶解，釋放細胞內代謝產物，引起代謝紊亂的一組綜閤徵，臨床特點為高尿痠血癥、高血鉀、高血燐、低血鈣、急性腎功能衰竭。積極預防、早期診斷和有效的治療可避免嚴重併髮癥的髮生。本文複習相關文獻以探討TLS髮生的病理機製、流行病學特徵、高危因素、臨床診斷、預防及治療。
종류용해종합정(Tumor lysis syndrome，TLS)시혈액계통악성병중교상견적조기엄중병발증，야가발생우기타악성종류。TLS시유우종류세포단기내대량용해，석방세포내대사산물，인기대사문란적일조종합정，림상특점위고뇨산혈증、고혈갑、고혈린、저혈개、급성신공능쇠갈。적겁예방、조기진단화유효적치료가피면엄중병발증적발생。본문복습상관문헌이탐토TLS발생적병리궤제、류행병학특정、고위인소、림상진단、예방급치료。
Tumor lysis syndrome(tumor lysis syndrome,TLS) is a common severe early complication of malignant disease in blood system.It also can occur in other malignancies.TLS is due to the large number of tumor cells dissolved in the short term,and release the intracellular metabolites,which cause a group of metabolic disorders syndromes.Its clinical features are hyperuricemia, hyperkalemia,hyperphosphatemia,hypocalcemia,acute renal failure.Positive prevention.Early diagnosis and effective treatment can prevent serious complications.In this paper,we review the relevant literature to explore pathological mechanism,epidemiology, risk factors,clinical diagnosis,prevention and treatment of TLS.
