CAJ | 학술논문

神经是皮肤感觉和体温调节等生理功能的基础，也通过多种机制调控创伤再生和瘢痕愈合等病理过程。尽管失神经支配的皮肤伤口能够愈合，但神经通过启动神经源性炎症反应和神经营养作用增加伤口周围组织的血供，促进成纤维细胞和角质形成细胞增殖和Ⅰ型、Ⅲ型胶原的表达，与免疫系统的相互作用和释放神经肽等机制促进皮肤伤口愈合。如果各种参与修复细胞、细胞外基质、神经血管和皮肤附属器能有机装配则再生修复，否则瘢痕愈合。神经自身主要在创伤修复早期和瘢痕塑形期通过轴突的生长修复，其生长速度明显较肉芽组织形成和瘢痕化慢。而且，不同神经纤维的轴突生长也不完全相同。外源性神经肽可促进难愈性伤口愈合，神经肽拮抗剂或高选择神经切断等失神经措施可减轻瘢痕增生。因此，了解神经和各种修复成分在创伤再生修复与瘢痕愈合中的作用和调控机制，有助于寻找促进皮肤和周围神经损伤再生修复的方法。
신경시피부감각화체온조절등생리공능적기출，야통과다충궤제조공창상재생화반흔유합등병리과정。진관실신경지배적피부상구능구유합，단신경통과계동신경원성염증반응화신경영양작용증가상구주위조직적혈공，촉진성섬유세포화각질형성세포증식화Ⅰ형、Ⅲ형효원적표체，여면역계통적상호작용화석방신경태등궤제촉진피부상구유합。여과각충삼여수복세포、세포외기질、신경혈관화피부부속기능유궤장배칙재생수복，부칙반흔유합。신경자신주요재창상수복조기화반흔소형기통과축돌적생장수복，기생장속도명현교육아조직형성화반흔화만。이차，불동신경섬유적축돌생장야불완전상동。외원성신경태가촉진난유성상구유합，신경태길항제혹고선택신경절단등실신경조시가감경반흔증생。인차，료해신경화각충수복성분재창상재생수복여반흔유합중적작용화조공궤제，유조우심조촉진피부화주위신경손상재생수복적방법。
Nerve is the foundation of the physiological function such as the skin feeling and thermoregulation, and also regulates the re-generation and scar healing of skin wound by multiple mechanisms. Though the denervated skin wound can heal spontaneously, the nerve might accelerate wound healing by activating the neurogenic inflammation and nerve trophism, increasing the blood supply around the wound, promoting the proliferation of fibroblasts and keratinocytes, stimulating the expression of collagen I and III, and interacting with im-mune system and releasing neuropeptides. If all kinds of repair cells, extracellular matrix, nerve, blood vessel and cutaneous appendages as-semble organically, the skin wound regenerates, and otherwise the scar heals. The nerve axon growth occurs mainly in the early stage of the wound healing and the scar rebuilding process, and the nerve growth rate is obviously slower than the granulation tissue formation and cica-trization. Furthermore, the axon growth of different nerve fibers are not entirely the same. The exogenous neuropeptides might promote the wound repair and the nerve regeneration. The antagonist of the neuropeptides or high selective nerve abscission might reduce the scar hyper-plasia. Therefore, it contribute to find methods to promote the regeneration of skin wound and peripheral nerve injury by understanding the effects and regulatory mechanism of both nerve and various repair elements in regeneration or scar healing of skin wound.