CAJ | 학술논문

目的：探讨高血压伴抑郁症与外周血干细胞因子（SCF）及其受体（c-kit）表达水平的关系。方法选择2013年2—12月江宁区第二人民医院精神科病区、内科与神经精神科门诊初诊的高血压患者147例，其中高血压伴抑郁症患者77例为试验组，高血压不伴抑郁症患者70例为对照组。从试验组中抽取37例患者进行12周抗抑郁治疗，为治疗组。采用酶联免疫吸附法检测外周血 SCF、 c-kit水平，放射免疫法检测内皮素1及白介素（ IL）6水平，采用Logistic回归分析高血压伴抑郁的影响因素。结果试验组与对照组比较， SCF 〔（848±22）、（917±32） ng／L〕、 c-kit 〔（11.9±3.7）、（13.1±4.1）μg／L〕水平降低，差异均有统计学意义（P＜0.05）；内皮素1〔（165±21）、（151±17） ng／L〕、 IL-6〔（97.3±12.1）、（86.2±9.8） ng／L〕水平升高，差异均有统计学意义（P＜0.05）；治疗组治疗后与治疗前比较， SCF 〔（873±25）、（852±19） ng／L〕、 c-kit 〔（12.7±3.1）、（11.4±3.5）μg／L〕水平升高，差异均有统计学意义（P＜0.05），内皮素1〔（140±15）、（166±20） ng／L〕、 IL-6〔（46.5±9.7）、（97.9±11.4） ng／L〕水平降低，差异均有统计学意义（P＜0.05）。 Logistic回归分析显示，低SCF （OR＝24.779， P＝0.002），低c-kit （OR＝79.998， P＝0.001），高内皮素1（OR＝27.688， P＝0.013）和高IL-6（OR＝198.343， P＜0.001）是高血压伴抑郁症的影响因素。结论高血压伴有抑郁症患者外周血中SCF、 c-kit表达水平较单纯高血压患者低，外周血中低SCF、 c-kit与高血压伴抑郁症相关；抗抑郁治疗可使外周血中SCF、 c-kit表达水平升高。
목적：탐토고혈압반억욱증여외주혈간세포인자（SCF）급기수체（c-kit）표체수평적관계。방법선택2013년2—12월강저구제이인민의원정신과병구、내과여신경정신과문진초진적고혈압환자147례，기중고혈압반억욱증환자77례위시험조，고혈압불반억욱증환자70례위대조조。종시험조중추취37례환자진행12주항억욱치료，위치료조。채용매련면역흡부법검측외주혈 SCF、 c-kit수평，방사면역법검측내피소1급백개소（ IL）6수평，채용Logistic회귀분석고혈압반억욱적영향인소。결과시험조여대조조비교， SCF 〔（848±22）、（917±32） ng／L〕、 c-kit 〔（11.9±3.7）、（13.1±4.1）μg／L〕수평강저，차이균유통계학의의（P＜0.05）；내피소1〔（165±21）、（151±17） ng／L〕、 IL-6〔（97.3±12.1）、（86.2±9.8） ng／L〕수평승고，차이균유통계학의의（P＜0.05）；치료조치료후여치료전비교， SCF 〔（873±25）、（852±19） ng／L〕、 c-kit 〔（12.7±3.1）、（11.4±3.5）μg／L〕수평승고，차이균유통계학의의（P＜0.05），내피소1〔（140±15）、（166±20） ng／L〕、 IL-6〔（46.5±9.7）、（97.9±11.4） ng／L〕수평강저，차이균유통계학의의（P＜0.05）。 Logistic회귀분석현시，저SCF （OR＝24.779， P＝0.002），저c-kit （OR＝79.998， P＝0.001），고내피소1（OR＝27.688， P＝0.013）화고IL-6（OR＝198.343， P＜0.001）시고혈압반억욱증적영향인소。결론고혈압반유억욱증환자외주혈중SCF、 c-kit표체수평교단순고혈압환자저，외주혈중저SCF、 c-kit여고혈압반억욱증상관；항억욱치료가사외주혈중SCF、 c-kit표체수평승고。
Objective To investigate the relationship between hypertension complicated with depression and the expression of peripheral blood stem cell factor ( SCF) /c-kit.Methods A total of 147 outpatients with hypertension who paid their first visit to the psychiatric ward , the Department of Internal Medicine and Department of Neuropsychiatry the Second People′s Hospital of Jiangning District from February to December in 2013 were enrolled and divided into two groups according to the presence and absence of depression: contol group ( n=70, hypertensive patients without depression ) and experimental group (n=77, hypertensive patients with depression ).From experimental group, we selected 37 subjects as treatment group , which 12-week anti-depression treatment was conducted .The expression levels of SCF and its receptor c -kit in peripheral blood were measured by enzyme -linked immunosorbent assay method .Endothelin -1 ( ET-1 ) and interleukin 6 ( IL-6 ) in peripheral blood were determined by radioimmunity assay .Logistic regression analysis was conducted to determine influencing factors for hypertension complicated with depression .Results The experimental group was lower ( P<0.05) than the control group in the expression levels of SCF 〔 ( 848 ±22 ) , ( 917 ±32 ) ng/L〕 and c -kit 〔 ( 11.9 ±3.7 ) , ( 13.1 ±4.1 ) μg/L〕; the experimental group was higher (P<0.05) than the control group in the expression levels of ET -1 〔 (165 ±21), (151 ±17) ng/L〕 and IL-6 〔 (97.3 ±12.1), (86.2 ±9.8) ng/L〕; the treatment group had higher (P<0.05) expression levels of SCF 〔 (873 ±25), (852 ±19) ng/L〕 and c-kit 〔 (12.7 ±3.1), (11.4 ±3.5) μg/L〕 after treatment than those before treatment; the treatment group had lower (P<0.05) expression levels of ET-1 〔 (140 ±15), (166 ±20) ng/L〕 and IL-6〔(46.5 ±9.7), (97.9 ±11.4) ng/L〕 after treatment than those before treatment .Logistic regression analyses indicated that the lower levels of SCF (OR=24.779, P=0.002) and c-kit (OR=79.998, P=0.001), and higher levels of ET -1 (OR=27.688, P=0.013 ) and IL-6 ( OR =198.343, P <0.001 ) were influencing factors for hypertension complicated with depression .Conclusion Patients with hypertension complicated with depression have higher levels of SCF and c -kit than patients with pure hypertension .Hypertension complicated with depression is associated with lower levels of SCF and c -kit. Raising the levels of SCF and c -kit may help with the anti -depression treatment .