中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2015年
4期
389-391
,共3页
罗建军%赖祯平%韦荣耀%邓亨平%吴龙飞
囉建軍%賴禎平%韋榮耀%鄧亨平%吳龍飛
라건군%뢰정평%위영요%산형평%오룡비
血管成形术%冠心病%血流动力学%细胞因子类
血管成形術%冠心病%血流動力學%細胞因子類
혈관성형술%관심병%혈류동역학%세포인자류
Angioplasty%Coronary disease%Hemodynamics%Cytokines
目的:分析冠状动脉介入干预对患者血流动力学及血清炎性因子水平的影响。方法选取76例冠心病患者,依据患者接受的介入操作不同分为观察组(PCI 术)41例,对照组(常规冠状动脉造影检查)35例。比较两组患者介入手术相关资料,包括:造影剂使用量、校正的 TIMI 帧数(CTFC)、平均动脉压等;比较两组患者术后24 h 血清炎性因子指标;分析观察组患者术后 CTFC 与白介素-6(IL-6)及金属蛋白酶-9(MMP-9)的相关性。结果观察组患者造影剂使用量显著高于对照组(t =6.371,P <0.01);观察组术后校正的 TIMI 帧数(CTFC)显著高于对照组(t =4.937,P <0.01);观察组术后平均动脉压水平显著高于对照组(t =4.499,P <0.01)。观察组患者术后24 h 血清 IL-6显著高于对照组(t =3.031,P <0.01);观察组术后25 h 血清 MMP-9显著高于对照组(t =3.920,P <0.01)。相关性分析显示,观察组患者术后血清 IL-6水平与术后 CTFC 呈现显著正相关(r =0.700,P <0.01);观察组患者术后血清 MMP-9水平与术后 CTFC 水平呈现正相关,差异有统计学意义(r =0.738,P <0.01)。结论PCI 术可导致患者血清炎性因子水平升高,且与冠脉血流呈现负相关。
目的:分析冠狀動脈介入榦預對患者血流動力學及血清炎性因子水平的影響。方法選取76例冠心病患者,依據患者接受的介入操作不同分為觀察組(PCI 術)41例,對照組(常規冠狀動脈造影檢查)35例。比較兩組患者介入手術相關資料,包括:造影劑使用量、校正的 TIMI 幀數(CTFC)、平均動脈壓等;比較兩組患者術後24 h 血清炎性因子指標;分析觀察組患者術後 CTFC 與白介素-6(IL-6)及金屬蛋白酶-9(MMP-9)的相關性。結果觀察組患者造影劑使用量顯著高于對照組(t =6.371,P <0.01);觀察組術後校正的 TIMI 幀數(CTFC)顯著高于對照組(t =4.937,P <0.01);觀察組術後平均動脈壓水平顯著高于對照組(t =4.499,P <0.01)。觀察組患者術後24 h 血清 IL-6顯著高于對照組(t =3.031,P <0.01);觀察組術後25 h 血清 MMP-9顯著高于對照組(t =3.920,P <0.01)。相關性分析顯示,觀察組患者術後血清 IL-6水平與術後 CTFC 呈現顯著正相關(r =0.700,P <0.01);觀察組患者術後血清 MMP-9水平與術後 CTFC 水平呈現正相關,差異有統計學意義(r =0.738,P <0.01)。結論PCI 術可導緻患者血清炎性因子水平升高,且與冠脈血流呈現負相關。
목적:분석관상동맥개입간예대환자혈류동역학급혈청염성인자수평적영향。방법선취76례관심병환자,의거환자접수적개입조작불동분위관찰조(PCI 술)41례,대조조(상규관상동맥조영검사)35례。비교량조환자개입수술상관자료,포괄:조영제사용량、교정적 TIMI 정수(CTFC)、평균동맥압등;비교량조환자술후24 h 혈청염성인자지표;분석관찰조환자술후 CTFC 여백개소-6(IL-6)급금속단백매-9(MMP-9)적상관성。결과관찰조환자조영제사용량현저고우대조조(t =6.371,P <0.01);관찰조술후교정적 TIMI 정수(CTFC)현저고우대조조(t =4.937,P <0.01);관찰조술후평균동맥압수평현저고우대조조(t =4.499,P <0.01)。관찰조환자술후24 h 혈청 IL-6현저고우대조조(t =3.031,P <0.01);관찰조술후25 h 혈청 MMP-9현저고우대조조(t =3.920,P <0.01)。상관성분석현시,관찰조환자술후혈청 IL-6수평여술후 CTFC 정현현저정상관(r =0.700,P <0.01);관찰조환자술후혈청 MMP-9수평여술후 CTFC 수평정현정상관,차이유통계학의의(r =0.738,P <0.01)。결론PCI 술가도치환자혈청염성인자수평승고,차여관맥혈류정현부상관。
Objective To analyze the effect of percutaneous coronary intervention (PCI)on blood flow dynam-ics and serum cytokines of patients.Methods Seventy-six patients with coronary heart disease were divided into obser-vation (PCI,n =41)and control (coronary angiography,n =35 )groups .Results The contrast agent usage of obser-vation group was significantly higher than control group (t =6.371,P <0.01).The mean arterial pressure and CTFC were significantly higher than those in control group(P <0.01).The levels of serum IL-6 at 24 hours postoperatively and MMP-9 at 25 hours postoperatively were significantly higher than those in control group (P <0.01).The correlation analysis showed that serum IL-6 and MMP-9 were positly associated with CTFC of postoperation (P <0.01).Conclusion PCI can cause serum cytokines increased,which was negative associated with coronary blood flow in CHD patients.