CAJ | 학술논문

目的：探讨研究老年2型糖尿病患者血糖波动与颈动脉内膜增厚、斑块形成的关系。方法选择89例老年2型糖尿病患者作为研究对象，按照颈动脉彩色多普勒超声显像结果将患者分为颈动脉正常组（46例）和颈动脉病变组（43例）。所有研究对象接受动态血糖监测系统（CGMS）连续72 h 的血糖监测，分析两组患者的血糖水平、糖化血红蛋白（HbAl c）、平均血糖浓度及一般生化指标的差异。结果颈动脉病变组的 lnHOMA-IR、HbAl c、低密度脂蛋白胆固醇（LDL-C）、收缩压（SBP）高于颈动脉正常组（P ＜0．05）；颈动脉病变组标准差（SD）、血糖波动最大幅度值（LAGE）、平均空腹血糖（MFBG）和变异系数（CV）值均显著高于颈动脉正常组（P ＜0．05）；多元回归分析结果显示 lnHOMA-IR、MPBG、LAGE 与内膜中层厚度显著相关，回归系数分别为0．012、0．104、0．176（P 均＜0．05）。结论血糖波动是老年2型糖尿病患者发生颈动脉内膜增厚和斑块发生的危险因素。
목적：탐토연구노년2형당뇨병환자혈당파동여경동맥내막증후、반괴형성적관계。방법선택89례노년2형당뇨병환자작위연구대상，안조경동맥채색다보륵초성현상결과장환자분위경동맥정상조（46례）화경동맥병변조（43례）。소유연구대상접수동태혈당감측계통（CGMS）련속72 h 적혈당감측，분석량조환자적혈당수평、당화혈홍단백（HbAl c）、평균혈당농도급일반생화지표적차이。결과경동맥병변조적 lnHOMA-IR、HbAl c、저밀도지단백담고순（LDL-C）、수축압（SBP）고우경동맥정상조（P ＜0．05）；경동맥병변조표준차（SD）、혈당파동최대폭도치（LAGE）、평균공복혈당（MFBG）화변이계수（CV）치균현저고우경동맥정상조（P ＜0．05）；다원회귀분석결과현시 lnHOMA-IR、MPBG、LAGE 여내막중층후도현저상관，회귀계수분별위0．012、0．104、0．176（P 균＜0．05）。결론혈당파동시노년2형당뇨병환자발생경동맥내막증후화반괴발생적위험인소。
Objective To investigate the relationship between blood glucose fluctuation and carotid intima media thickness,plaque formation in the elderly patients with type 2 diabetes mellitus.Method 89 cases of elderly patients with type 2 diabetes were collected and divided into the normal carotid artery group(46 cases)and carotid ar-tery disease group(43 cases)according to the results of carotid artery color Doppler ultrasonography.All subjects un-derwent continuous glucose monitoring system(CGMS)for 72 hours of continuous glucose monitoring,The blood glu-cose levels,glycosylated hemoglobin,mean blood glucose concentration and biochemical indexes were observed and compared between the two groups.Results The lnHOMA-IR,HbAl c,LDL-C and SBP in carotid artery disease group were higher than those in normal group,and the difference was statistically significant(P <0.05).The duration of ca-rotid artery disease in patients with diabetes group(11.8 ±2.36)was longer than that in the normal group(7.3 ± 1.46years)(P <0.05);the SD,LAGE,MPGE and CV levels in Carotid artery disease group were significantly higher than those in normal group,there were significant difference between the two groups(P <0.05);The results of multi-ple regression analysis showed IMT was significantly correlated with lnHOMA-IR,MPBGand LAGE,the regression co-efficients were 0.012,0.104 and 0.176 respectively(P <0.05).Conclusion The intimal thickening and plaque for-mation is related to blood glucose fluctuation in the elderly type 2 diabetic patients with carotid artery.