CAJ | 학술논문

目的：研究亚临床甲状腺功能减退（亚临床甲减）对老年冠状动脉粥样硬化性心脏病（冠心病）患者代谢因素的影响。方法选取183例老年冠心病患者，其中合并亚临床甲减者78例，无合并亚临床甲减者105例，两组患者分别抽空腹血检测血清促甲状腺素（TSH）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、尿酸（UA）、空腹血糖（FPG）及 C 反应蛋白（CRP）的水平，进行两组间比较。结果与无亚临床甲减的冠心病患者比较，合并亚临床甲减的冠心病患者血 TG、TC 、CRP、UA、LDL 水平均明显升高、HDL 水平降低，差异有统计学意义（P ＜0．05或 P ＜0．01）。两组患者空腹血糖（FPG）水平差异无统计学意义（P ＞0．05）。结论亚临床甲减加重老年冠心病患者的血脂、尿酸等代谢紊乱。
목적：연구아림상갑상선공능감퇴（아림상갑감）대노년관상동맥죽양경화성심장병（관심병）환자대사인소적영향。방법선취183례노년관심병환자，기중합병아림상갑감자78례，무합병아림상갑감자105례，량조환자분별추공복혈검측혈청촉갑상선소（TSH）、삼선감유（TG）、총담고순（TC）、고밀도지단백（HDL）、저밀도지단백（LDL）、뇨산（UA）、공복혈당（FPG）급 C 반응단백（CRP）적수평，진행량조간비교。결과여무아림상갑감적관심병환자비교，합병아림상갑감적관심병환자혈 TG、TC 、CRP、UA、LDL 수평균명현승고、HDL 수평강저，차이유통계학의의（P ＜0．05혹 P ＜0．01）。량조환자공복혈당（FPG）수평차이무통계학의의（P ＞0．05）。결론아림상갑감가중노년관심병환자적혈지、뇨산등대사문란。
Objective To study the influence of subclinical hypothyroidism on metabolic factors of elderly patients with coronary atherosclerotic heart disease (CHD).Methods We selected 183 cases of elderly with coro-nary artery disease,including 78 cases combined with subclinical hypothyroidism,and 105 patients without subclinical hypothyroidism.Two groups of patients were detected the serum thyroid stimulating hormone (TSH),triglyceride (TG),total cholesterol (TC),high density lipoprotein (HDL),low density lipoprotein (LDL),uric acid (UA),fast-ing blood glucose (FPG)and C reactive protein (CRP)level,and the detected parameters were compared between groups.Results Compared with without subclinical hypothyroidism groups,TG,TC,CRP,UA,LDL levels of the pa-tients in eldly with CHD were obviously higher.The differences were statistically significant (P <0.05 or P <0.01). Conclusion Subclinical hypothyroidism aggravated metabolic disorders of lipid and uric acid in aged patients with coronary heart disease.