CAJ | 학술논문

成人发病的散发性共济失调症是由多种原因所致，临床表现以共济失调为主要的多种疾病。致病原因包括中毒、免疫介导性、维生素缺乏、感染性疾病、变性病以及遗传性疾患等。散发性共济失调临床谱具有明显异质性，临床正确诊断极具挑战性。但相比于遗传性共济失调症，此类疾患多数治疗效果较好，及时、正确诊断尤为重要。现代生化、免疫以及影像学技术有助于此类疾患的认识和诊治。文中综述并讨论可致成人发病的散发性共济失调的不同疾病分类，并着重其临床和神经影像学表现及诊断标准。
성인발병적산발성공제실조증시유다충원인소치，림상표현이공제실조위주요적다충질병。치병원인포괄중독、면역개도성、유생소결핍、감염성질병、변성병이급유전성질환등。산발성공제실조림상보구유명현이질성，림상정학진단겁구도전성。단상비우유전성공제실조증，차류질환다수치료효과교호，급시、정학진단우위중요。현대생화、면역이급영상학기술유조우차류질환적인식화진치。문중종술병토론가치성인발병적산발성공제실조적불동질병분류，병착중기림상화신경영상학표현급진단표준。
Adult-onset sporadic ataxias are a group of disorders manifested predominantly with ataxia, due to a variety of the potential causes including intoxication, immune-mediation, vitamins deifciencies, infections, neurodegeneration, and even some hereditary conditions. The clinical spectrum of these disorders is diverse, and their diagnosis remains a challenge. Compared with hereditary ataxias, most ataxias in this group respond the treatment well, that means the signiifcance of timely and correct diagnosis. The advanced biochemical, immune and imaging tools will help the perception and management on those ataxias. Different categories of adult-onset sporadic ataxia were elucidated with the highlight on their clinical features, neuro-imagingand diagnostic criteria.