CAJ | 학술논문

促分裂原活化蛋白激酶(MAPKs)家族是细胞内重要的信号传导系统，并在神经可塑性以及炎症反应方面发挥重要作用。MAPKs家族包括3个家庭成员：细胞外信号调节激酶、c-Jun氨基末端激酶和p38MAPK。p38 MAPK信号通路是MAPKs家族信号通路的枢纽，诱导多种与神经性病理疼痛相关的细胞内反应。p38 MAPK可以作为神经元和胶质细胞中研究疼痛的靶标，为疼痛性疾病的治疗提供一个潜在治疗方案。
촉분렬원활화단백격매(MAPKs)가족시세포내중요적신호전도계통，병재신경가소성이급염증반응방면발휘중요작용。MAPKs가족포괄3개가정성원：세포외신호조절격매、c-Jun안기말단격매화p38MAPK。p38 MAPK신호통로시MAPKs가족신호통로적추뉴，유도다충여신경성병리동통상관적세포내반응。p38 MAPK가이작위신경원화효질세포중연구동통적파표，위동통성질병적치료제공일개잠재치료방안。
Mitogen-activated protein kinases (MAPKs) mainly included extracellular signal-regulated kinas (ERKs) family, the c-Jun NH2-terminal kinases (JNKs) family and p38 MAPKs family. They play a well-recognized role in neural plasticity and inlfammatory response. p38 MAPK signal transduction pathway is one of the multiple parallel MAPK signal transduction pathways, involving in the formation and maintenance of pain. p38 MAPK induces a variety of intracellular responses associated with neuropathic pain and other chronic pain. Thus, speciifc targeting p38 MAPK molecule and its signaling pathway represent potential therapeutic strategies for pain management.