CAJ | 학술논문

目的研究最小意识状态(MCS)患者对不同速度音乐和唤名刺激的脑电响应程度，观察不同声音对MCS促醒的影响，为选择何种声音作为促醒治疗的刺激方法提供理论支持。方法对21例MCS患者分别进行3种声音片段的刺激：音乐(快速，140BPM)、(慢速，80BPM)以及患者家属唤名，同步记录患者脑电波数据，分析3种声音片段感知过程中兹、α和β波段相对功率值(刺激时脑电波绝对功率值/安静状态脑电波绝对功率值)的差异。结果3种声音刺激的兹波段相对功率值无显著统计学差异(跃0.05)；慢速音乐的α波相对功率值高于快速音乐及唤名刺激，且有显著性差异(慢vs快<0.05，慢vs唤名<0.01)，慢速音乐的β波段相对功率值低于快速音乐及唤名刺激，且有显著性差异(慢vs快<0.05，慢vs唤名<0.01)；快速音乐与唤自名刺激间无显著差异(Pα波跃0.05，Pβ波跃0.05)。结论听音乐可提高MCS患者皮层的信息整合能力，而快速音乐引起的脑功能皮层区之间的协同作用更强；MCS患者对唤自名刺激比音乐刺激的脑电响应程度大。
목적연구최소의식상태(MCS)환자대불동속도음악화환명자격적뇌전향응정도，관찰불동성음대MCS촉성적영향，위선택하충성음작위촉성치료적자격방법제공이론지지。방법대21례MCS환자분별진행3충성음편단적자격：음악(쾌속，140BPM)、(만속，80BPM)이급환자가속환명，동보기록환자뇌전파수거，분석3충성음편단감지과정중자、α화β파단상대공솔치(자격시뇌전파절대공솔치/안정상태뇌전파절대공솔치)적차이。결과3충성음자격적자파단상대공솔치무현저통계학차이(약0.05)；만속음악적α파상대공솔치고우쾌속음악급환명자격，차유현저성차이(만vs쾌<0.05，만vs환명<0.01)，만속음악적β파단상대공솔치저우쾌속음악급환명자격，차유현저성차이(만vs쾌<0.05，만vs환명<0.01)；쾌속음악여환자명자격간무현저차이(Pα파약0.05，Pβ파약0.05)。결론은음악가제고MCS환자피층적신식정합능력，이쾌속음악인기적뇌공능피층구지간적협동작용경강；MCS환자대환자명자격비음악자격적뇌전향응정도대。
Objective Electroencephalogram (EEG) response of minimal y conscious state ( MCS) patient to dif erent sound stimuli was explored to provide theoretical basis for clinical awaking therapy of patients in an MCS.Methods 21 patients in an MCS were enrol ed in this study, patients were presented with 3 kinds of sound clips which were fast tempo music (140BPM), slow tempo music (80BPM) and cal ing of patient’s own name by their next of kin, while recording EEG data simultaneously. relative power values (RPVs) of θ,αandβwaves in EEG (absolute power values (APVs) in stimulation to APVs at rest) across three audio clippings compared and the schema of the variations of APVs in stimulation recognized. Results There was no significant statistical dif erence in RPVs of θwaves in three types of acoustic stimuli ( >0.05);RPVs ofαwaves under lento were higher than al egro or appel ation from kin, with significant statistical dif erences (PL vs A<0.05, PA vs AK<0.01);while RPVs ofβwaves were lower than al egro or appel ation from kin, with significant statistical dif erence (PL vs A<0.05, PL vs AK<0.01). However, there were no statistical dif erences in RPVs of bothαandβwaves under stimulation by music in al egro or appel ation from kin ( α>0.05, β>0.05). Conclusion Audition of music promotes the information integration by the cerebral cortex in patients with MCS, in which music in al egro fortifies the synergistic ef ects across the functional areas in cerebral cortex.;While,Stimulations by appel ations from kin arouse greater variations of EEG in MCS patients than do music genre.