中华危重症医学杂志（电子版）
中華危重癥醫學雜誌（電子版）
중화위중증의학잡지（전자판）
CHINESE JOURNAL OF CRITICAL CARE MEDICINE ( ELECTRONIC EDITON)
2015年
2期
104-108
,共5页
重型颅脑损伤%8-异前列腺素F2α%预后
重型顱腦損傷%8-異前列腺素F2α%預後
중형로뇌손상%8-이전렬선소F2α%예후
Severe craniocerebral injury%8-iso prostaglandin F2α%Prognosis
目的：分析血浆8-异前列腺素F2α（8-iso-PGF2α）水平与重型颅脑损伤（STBI）患者外伤严重程度及6个月死亡的关系。方法选取120例STBI患者（外伤组）及120例健康体检者（对照组）作回顾性研究。用酶联免疫吸附试验检测两组血浆8-iso-PGF2α浓度，采用多元线性回归分析法分析其与外伤严重程度的关系。采用受试者工作特征曲线分析血浆8-iso-PGF2α浓度对外伤后6个月死亡的预测价值。结果外伤组血浆8-iso-PGF2α水平高于对照组（t=17.682， P<0.001）。血浆8-iso-PGF2α水平与STBI患者格拉斯哥昏迷评分呈负相关（t=-5.780，P<0.001），且是外伤后6个月死亡的独立危险因素（OR=1.007，95%CI=1.004～1.010，P<0.001）。血浆8-iso-PGF2α水平可预测外伤后6个月死亡（灵敏度：0.82，特异度：0.64，曲线下面积=0.826，95%CI=0.747~0.889）。结论 STBI患者血浆8-iso-PGF2α水平升高，且与其外伤严重度及长期预后密切相关。
目的：分析血漿8-異前列腺素F2α（8-iso-PGF2α）水平與重型顱腦損傷（STBI）患者外傷嚴重程度及6箇月死亡的關繫。方法選取120例STBI患者（外傷組）及120例健康體檢者（對照組）作迴顧性研究。用酶聯免疫吸附試驗檢測兩組血漿8-iso-PGF2α濃度，採用多元線性迴歸分析法分析其與外傷嚴重程度的關繫。採用受試者工作特徵麯線分析血漿8-iso-PGF2α濃度對外傷後6箇月死亡的預測價值。結果外傷組血漿8-iso-PGF2α水平高于對照組（t=17.682， P<0.001）。血漿8-iso-PGF2α水平與STBI患者格拉斯哥昏迷評分呈負相關（t=-5.780，P<0.001），且是外傷後6箇月死亡的獨立危險因素（OR=1.007，95%CI=1.004～1.010，P<0.001）。血漿8-iso-PGF2α水平可預測外傷後6箇月死亡（靈敏度：0.82，特異度：0.64，麯線下麵積=0.826，95%CI=0.747~0.889）。結論 STBI患者血漿8-iso-PGF2α水平升高，且與其外傷嚴重度及長期預後密切相關。
목적：분석혈장8-이전렬선소F2α（8-iso-PGF2α）수평여중형로뇌손상（STBI）환자외상엄중정도급6개월사망적관계。방법선취120례STBI환자（외상조）급120례건강체검자（대조조）작회고성연구。용매련면역흡부시험검측량조혈장8-iso-PGF2α농도，채용다원선성회귀분석법분석기여외상엄중정도적관계。채용수시자공작특정곡선분석혈장8-iso-PGF2α농도대외상후6개월사망적예측개치。결과외상조혈장8-iso-PGF2α수평고우대조조（t=17.682， P<0.001）。혈장8-iso-PGF2α수평여STBI환자격랍사가혼미평분정부상관（t=-5.780，P<0.001），차시외상후6개월사망적독립위험인소（OR=1.007，95%CI=1.004～1.010，P<0.001）。혈장8-iso-PGF2α수평가예측외상후6개월사망（령민도：0.82，특이도：0.64，곡선하면적=0.826，95%CI=0.747~0.889）。결론 STBI환자혈장8-iso-PGF2α수평승고，차여기외상엄중도급장기예후밀절상관。
Objective To investigate the clinical significance and prognostic value of plasma 8-iso-Prostaglandin F2α (8-iso-PGF2α) level in patents with severe traumatic brain injury (STBI). Methods A total of 120 patients with STBI (trauma group) and 120 healthy controls (control group) were enrolled in the retrospective study. Plasma 8-iso-PGF2α concentrations of all the cases were measured by enzyme linked immunosorbent assay. The relationship between the plasma 8-iso-PGF2α level and the trauma severity was analyzed by using multivariate linear regression. The predictive value of 8-iso-PGF2α for 6-month mortality was determined by ROC curve. Results Plasma 8-iso-PGF2α concentrations in the trauma group were substantially higher than those in the control group (t = 17.682, P < 0.001). Plasma 8-iso-PGF2α levels which were inversely related to Glasgow coma scale scores (t=-5.780, P<0.001), were also an independent risk factor for 6-month mortality of STBI patients (OR=1.007, 95%CI=1.004-1.010, P < 0.001). Plasma 8-iso-PGF2α level can statistically predict 6-month mortality of STBI patients (sensitivity:0.82, specificity:0.64, area under the curve=0.826, 95%CI = 0.747-0.889). Conclusions Plasma 8-iso-PGF2α levels were raised in STBI patients. It has a negative correlation with trauma severity, and also affects the long-term mortality in STBI patients.
