首都食品与医药
首都食品與醫藥
수도식품여의약
Capital Medicine
2015年
16期
80-81
,共2页
心力衰竭%脑利钠肽%心肌梗死%硝普钠
心力衰竭%腦利鈉肽%心肌梗死%硝普鈉
심력쇠갈%뇌리납태%심기경사%초보납
heart failure%sodium nitropusside%natriure peptide%myocardial infarction
目的：对比研究硝普钠和重组人脑利钠肽（rhBNP）分别对急性心肌梗死（AMI）合并急性心力衰竭（AHF）的临床疗效。方法随机选择心功能三级并没有心源性休克、AMI并AHF的患者56例，随机分为A组（rhBNP组）和B组（硝普钠组），在静脉应用呋塞米针剂治疗心力衰竭和标准抗缺血治疗基础上，依次加用rhBNP和硝普钠，分别观察两组患者24小时液体出入量，72小时后左心室舒张末期内径（LVEDD）、血清脑钠肽（BNP）水平、左心室射血分数（LVEF）。结果 A组用药24小时后尿量及出入量差值明显高于B组，72小时后两组患者LVEDD及BNP水平均较前显著下降，LVEF均明显上升，但A组升高和降低的幅度均较B组高。结论相比硝普钠而言，rhBNP更能改善AMI合并AHF患者的血流动力学表现和临床症状，效果显著。
目的：對比研究硝普鈉和重組人腦利鈉肽（rhBNP）分彆對急性心肌梗死（AMI）閤併急性心力衰竭（AHF）的臨床療效。方法隨機選擇心功能三級併沒有心源性休剋、AMI併AHF的患者56例，隨機分為A組（rhBNP組）和B組（硝普鈉組），在靜脈應用呋塞米針劑治療心力衰竭和標準抗缺血治療基礎上，依次加用rhBNP和硝普鈉，分彆觀察兩組患者24小時液體齣入量，72小時後左心室舒張末期內徑（LVEDD）、血清腦鈉肽（BNP）水平、左心室射血分數（LVEF）。結果 A組用藥24小時後尿量及齣入量差值明顯高于B組，72小時後兩組患者LVEDD及BNP水平均較前顯著下降，LVEF均明顯上升，但A組升高和降低的幅度均較B組高。結論相比硝普鈉而言，rhBNP更能改善AMI閤併AHF患者的血流動力學錶現和臨床癥狀，效果顯著。
목적：대비연구초보납화중조인뇌리납태（rhBNP）분별대급성심기경사（AMI）합병급성심력쇠갈（AHF）적림상료효。방법수궤선택심공능삼급병몰유심원성휴극、AMI병AHF적환자56례，수궤분위A조（rhBNP조）화B조（초보납조），재정맥응용부새미침제치료심력쇠갈화표준항결혈치료기출상，의차가용rhBNP화초보납，분별관찰량조환자24소시액체출입량，72소시후좌심실서장말기내경（LVEDD）、혈청뇌납태（BNP）수평、좌심실사혈분수（LVEF）。결과 A조용약24소시후뇨량급출입량차치명현고우B조，72소시후량조환자LVEDD급BNP수평균교전현저하강，LVEF균명현상승，단A조승고화강저적폭도균교B조고。결론상비초보납이언，rhBNP경능개선AMI합병AHF환자적혈류동역학표현화림상증상，효과현저。
ObjectiveTo compare the clinical efficacy of recombinant human brain natriuretic peptide(rhBNP) and sodium nitroprusside(SNP) in acute myocardial infarction(AMI) complicated with acute heart failure(AHF).Methods The study enrolled 56 AMI patients complicated with AHF but without cardiogenic shock, their cardiac functions were classified Killip Ⅲ, and the patients were randomly divided into two groups: rhBNP group and SNP group. On the basis of standard anti-ischemic treatment and anti-heart failure treatment by intravenous injection of furosemide, the two groups were treated with rhBNP and SNP, respectively, The changes of liquid intake and output after 24 hours’ treatment, blood brain natriuretic peptide(BNP), left ventricular end-diastolic dimension(LVEDD), left ventricular ejection fraction(LVEF) before treatment and after 72 hours’treatment were observed.Results Compared with SNP group, the urine volume and the different value between the intake and output increased significantly in rhBNP group after 24 hours’treatment. Compared with before treatment, the blood BNP and LVEDD were decreased significantly and <br> the LVEF was increased significantly after 72 hours’treatment in both groups.Conclusion Compared witn SNP, rhBNP could significantly improve the hemodynamic and clinical symptoms in the patients witn AMI complicated witn AHF, and the clinical effects are exact.
