CAJ | 학술논문

目的：研究金黄凝胶的成型工艺，并建立其质量控制方法。方法：以凝胶剂的成型性、稳定性、失水率、pH等综合评分为指标，采用L9（3）4正交试验法，优选最佳成型工艺。采用TLC法鉴别本品中天花粉、大黄；采用HPLC法测定芍药苷含量。结果：最优处方为卡波姆940为1%、甘油10%、三乙醇胺0.5%；能采用TLC法检测天花粉、大黄，pH在5.00-5.15之间；芍药苷的线性范围为29.04-945.20 mg·mL-1，平均回收率为98.80%，RSD为2.91%（n=9）。结论：金黄凝胶剂成型工艺简单、质量可控，方法可靠、稳定性好。
목적：연구금황응효적성형공예，병건립기질량공제방법。방법：이응효제적성형성、은정성、실수솔、pH등종합평분위지표，채용L9（3）4정교시험법，우선최가성형공예。채용TLC법감별본품중천화분、대황；채용HPLC법측정작약감함량。결과：최우처방위잡파모940위1%、감유10%、삼을순알0.5%；능채용TLC법검측천화분、대황，pH재5.00-5.15지간；작약감적선성범위위29.04-945.20 mg·mL-1，평균회수솔위98.80%，RSD위2.91%（n=9）。결론：금황응효제성형공예간단、질량가공，방법가고、은정성호。
This article is aimed to study the optimal process of preparation of Golden water-soluble gel, and to establish its quality control method. Taking the gel forming properties, stability, water loss rate, pH as investigation index, the best extraction process was screened by single factor and orthogonal test design. TLC method was used to identify the product of trichosanthin, rhubarb, and the content of paeoniflorin was determined by HPLC method. The optimal condition of preparation process is to use 1% carbomer as gel matrix, 10% glycerol as humectants, and 0.5%triethanolamine as pH modulators; trichosanthes and rhubarb could be detected by TLC method, with pH range 5.00 - 5.15. The linear range of paeoniflorin was 29.04-945.20μg·mL-1, the average recovery was 98.80%, and RSD was 2.91% (n=9). Golden gel forming process is simple and quality controllable with reliability and good stability.