临床肾脏病杂志
臨床腎髒病雜誌
림상신장병잡지
JOURNAL OF CLINICAL NEPHROLOGY
2015年
7期
422-426
,共5页
糖尿病肾脏疾病%蛋白激酶C-η%蛋白激酶C-ζ%血脂%炎性因子
糖尿病腎髒疾病%蛋白激酶C-η%蛋白激酶C-ζ%血脂%炎性因子
당뇨병신장질병%단백격매C-η%단백격매C-ζ%혈지%염성인자
Diabetic kidney disease%PKC-η%PKC-ζ%Hyperlipidemia%Inflammatory cytokines
目的：分析糖尿病肾脏疾病患者血清中蛋白激酶C-η(protein kinase C-η,PKC-η)、蛋白激酶C-ζ(protein kinase C-ζ,PKC-ζ)、血脂和炎性因子的表达情况以及 PKC-η、PKC-ζ与血脂和炎性因子的相关性。方法选择2010年6月到2014年6月黄石市中心医院肾内科收治的糖尿病肾脏疾病患者18例(观察组)；另选择健康体检人员20名为对照组。比较2组 PKC-η、PKC-ζ、血脂及炎性因子含量,并运用Pearson相关分析其相关性。结果观察组血尿素氮(BUN)、血肌酐(SCr)、血尿素、血尿酸、血总胆固醇(total cholesterol,TC)、三酰甘油(trilaurate glycerin,TG)、低密度脂蛋白胆固醇(low densith lipoprotein-cholesterol,LDL-C)、白细胞介素1α(inter leukin-1α,IL-1α)、白细胞介素1β(interleukin-1β,IL-1β)、白细胞介素6(interleukin-6,IL-6)以及肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)明显高于对照组,差异有统计学意义(P<0.05)；观察组内生肌酐清除率(creatinine clear-ance rate,Ccr)和高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)明显低于对照组,差异有统计学意义(P<0.05)；观察组 PKC-η和 PKC-ζ明显高于对照组,差异有统计学意义(P<0.05)。PKC-η、PKC-ζ分别与4个炎性因子相关性分析显示,PKC-η与 IL-1α、IL-1β、IL-6及 TNF-α成正相关(r=0.562、0.518、0.754、0.634,P<0.05)；PKC-ζ与 IL-1α、IL-1β、IL-6及 TNF-α成正相关(r=0.551、0.576、0.733、0.584,P<0.05)。PKC-η、PKC-ζ分别与血脂相关性分析显示,PKC-η与TC、TG、LDL-C 成正相关(r=0.566、0.538、0.604,P<0.05),PKC-η与 HDL-C 成负相关(r=-0.732,P<0.05)；PKC-ζ与TC、TG、LDL-C 成正相关(r=0.577、0.565、0.544,P<0.05)；PKC-ζ与 HDL-C成负相关(r=-0.721,P<0.05)。结论糖尿病肾脏疾病患者全血中 PKC-η和 PKC-ζ浓度明显升高,同时其与血脂(TC、TG、LDL-C 和 HDL-C)及炎性因子(IL-1α、IL-1β、IL-6和 TNF-α)有明显的相关性。
目的：分析糖尿病腎髒疾病患者血清中蛋白激酶C-η(protein kinase C-η,PKC-η)、蛋白激酶C-ζ(protein kinase C-ζ,PKC-ζ)、血脂和炎性因子的錶達情況以及 PKC-η、PKC-ζ與血脂和炎性因子的相關性。方法選擇2010年6月到2014年6月黃石市中心醫院腎內科收治的糖尿病腎髒疾病患者18例(觀察組)；另選擇健康體檢人員20名為對照組。比較2組 PKC-η、PKC-ζ、血脂及炎性因子含量,併運用Pearson相關分析其相關性。結果觀察組血尿素氮(BUN)、血肌酐(SCr)、血尿素、血尿痠、血總膽固醇(total cholesterol,TC)、三酰甘油(trilaurate glycerin,TG)、低密度脂蛋白膽固醇(low densith lipoprotein-cholesterol,LDL-C)、白細胞介素1α(inter leukin-1α,IL-1α)、白細胞介素1β(interleukin-1β,IL-1β)、白細胞介素6(interleukin-6,IL-6)以及腫瘤壞死因子α(tumor necrosis factor-α,TNF-α)明顯高于對照組,差異有統計學意義(P<0.05)；觀察組內生肌酐清除率(creatinine clear-ance rate,Ccr)和高密度脂蛋白膽固醇(high density lipoprotein-cholesterol,HDL-C)明顯低于對照組,差異有統計學意義(P<0.05)；觀察組 PKC-η和 PKC-ζ明顯高于對照組,差異有統計學意義(P<0.05)。PKC-η、PKC-ζ分彆與4箇炎性因子相關性分析顯示,PKC-η與 IL-1α、IL-1β、IL-6及 TNF-α成正相關(r=0.562、0.518、0.754、0.634,P<0.05)；PKC-ζ與 IL-1α、IL-1β、IL-6及 TNF-α成正相關(r=0.551、0.576、0.733、0.584,P<0.05)。PKC-η、PKC-ζ分彆與血脂相關性分析顯示,PKC-η與TC、TG、LDL-C 成正相關(r=0.566、0.538、0.604,P<0.05),PKC-η與 HDL-C 成負相關(r=-0.732,P<0.05)；PKC-ζ與TC、TG、LDL-C 成正相關(r=0.577、0.565、0.544,P<0.05)；PKC-ζ與 HDL-C成負相關(r=-0.721,P<0.05)。結論糖尿病腎髒疾病患者全血中 PKC-η和 PKC-ζ濃度明顯升高,同時其與血脂(TC、TG、LDL-C 和 HDL-C)及炎性因子(IL-1α、IL-1β、IL-6和 TNF-α)有明顯的相關性。
목적：분석당뇨병신장질병환자혈청중단백격매C-η(protein kinase C-η,PKC-η)、단백격매C-ζ(protein kinase C-ζ,PKC-ζ)、혈지화염성인자적표체정황이급 PKC-η、PKC-ζ여혈지화염성인자적상관성。방법선택2010년6월도2014년6월황석시중심의원신내과수치적당뇨병신장질병환자18례(관찰조)；령선택건강체검인원20명위대조조。비교2조 PKC-η、PKC-ζ、혈지급염성인자함량,병운용Pearson상관분석기상관성。결과관찰조혈뇨소담(BUN)、혈기항(SCr)、혈뇨소、혈뇨산、혈총담고순(total cholesterol,TC)、삼선감유(trilaurate glycerin,TG)、저밀도지단백담고순(low densith lipoprotein-cholesterol,LDL-C)、백세포개소1α(inter leukin-1α,IL-1α)、백세포개소1β(interleukin-1β,IL-1β)、백세포개소6(interleukin-6,IL-6)이급종류배사인자α(tumor necrosis factor-α,TNF-α)명현고우대조조,차이유통계학의의(P<0.05)；관찰조내생기항청제솔(creatinine clear-ance rate,Ccr)화고밀도지단백담고순(high density lipoprotein-cholesterol,HDL-C)명현저우대조조,차이유통계학의의(P<0.05)；관찰조 PKC-η화 PKC-ζ명현고우대조조,차이유통계학의의(P<0.05)。PKC-η、PKC-ζ분별여4개염성인자상관성분석현시,PKC-η여 IL-1α、IL-1β、IL-6급 TNF-α성정상관(r=0.562、0.518、0.754、0.634,P<0.05)；PKC-ζ여 IL-1α、IL-1β、IL-6급 TNF-α성정상관(r=0.551、0.576、0.733、0.584,P<0.05)。PKC-η、PKC-ζ분별여혈지상관성분석현시,PKC-η여TC、TG、LDL-C 성정상관(r=0.566、0.538、0.604,P<0.05),PKC-η여 HDL-C 성부상관(r=-0.732,P<0.05)；PKC-ζ여TC、TG、LDL-C 성정상관(r=0.577、0.565、0.544,P<0.05)；PKC-ζ여 HDL-C성부상관(r=-0.721,P<0.05)。결론당뇨병신장질병환자전혈중 PKC-η화 PKC-ζ농도명현승고,동시기여혈지(TC、TG、LDL-C 화 HDL-C)급염성인자(IL-1α、IL-1β、IL-6화 TNF-α)유명현적상관성。
Objective To analyze and discuss the correlation between the protein kinase C-η(PKC-η),protein kinase C-ζ(PKC-ζ)with blood lipids,inflammatory factors in patients with diabetic kidney disease (DKD).Methods Eighteen cases of DKD (observation group)treated in Huangshi Central Hospital from June 2010 to June 2014 and 20 cases of healthy volunteers (control group)were collected.PKC-η,PKC-ζ,blood lipids,and inflammatory factors were compared,and the correlation was analyzed by Pearson correlation analysis.Results The values of blood urea nitrogen (BUN),ser-um creatinine (SCr),blood urea,blood uric acid,total cholesterol (TC),trilaurate glycerin (TG), low density lipoprotein-cholesterol (LDL-C),interleukin-1α(IL-1α),IL-1β,IL-6 and tumor necrosis factor-α(TNF-α)in observation group were significantly higher than those in control group (P<0.05).The levels of creatinine clearance,and HDL-C in observation group were significantly lower than those in control group (P<0.05).The levels of PKC-ηand PKC-ζin observation group were ob-viously higher than those in control group (P<0.05).The correlation analysis revealed that PKC-ηwas positively correlated with IL-1α,IL-1β,IL-6 and TNF-α(r=0.562,0.518,0.754 and 0.634 re-spectively,P<0.05 );PKC-ζwas positively correlated with IL-1α,IL-1β,IL-6 and TNF-α(r=0.551,0.576,0.733 and 0.584 respectively,P<0.05).PKC-ηwas positively correlated with TC, TG and LDL-C (r=0.566,0.538,and 0.604 respectively,P<0.05).PKC-ηwas negatively correla-ted with HDL-C (r=-0.732,P<0.05).PKC-ζwas positively correlated with TC,TG and LDL-C (r=0.577,0.565 and 0.544 respectively,P<0.05).PKC-ζwas negatively correlated with HDL-C (r=-0.721,P<0.05).Conclusions PKC-ηand PKC-ζin patients with DKD were significantly in-creased,meanwhile they show obvious correlation with serum lipids (TC,TG,LDL-C,and HDL-C) and inflammatory factors (IL-1α,IL-1β,IL-6,and TNF-α).
