临床儿科杂志
臨床兒科雜誌
림상인과잡지
2015年
8期
730-733
,共4页
武苏%汪素美%朱子阳%顾威%倪世宁%石星%刘倩琦
武囌%汪素美%硃子暘%顧威%倪世寧%石星%劉倩琦
무소%왕소미%주자양%고위%예세저%석성%류천기
矮小症%病因%骨龄
矮小癥%病因%骨齡
왜소증%병인%골령
short stature%etiology%bone age
目的：探讨矮小症患儿的病因分类及其骨龄落后情况。方法回顾性分析2009年1月至2014年12月住院治疗2132例矮小症患儿的临床资料。结果2132例矮小症患儿中男1333例、女799例，平均年龄(9.03±3.04)岁，平均骨龄(6.81±3.05岁)；完全性生长激素缺乏症324例(15.20%)，部分性生长激素缺乏症780例(36.58%)，多垂体激素缺乏症27例(1.27%)，甲状腺功能减低症13例(0.61%)，特发性矮小893例(41.89%)，低出生体质量儿19例(0.89%)；骨骼发育障碍8例(0.38%)，颅内肿瘤13例(0.61%)，慢性系统性疾病15例(0.70%)，染色体疾病40例(1.88%)。ANOVA分析显示，不同病因组骨龄落后情况不同，多垂体激素缺乏症、颅内肿瘤导致的矮小症骨龄落后较其余各病因组明显。生长激素峰值与骨龄落后值之间存在负相关关系。结论生长激素缺乏症是矮小症最常见病因。矮小症患儿普遍存在骨龄落后，骨龄落后值与生长激素峰值之间存在负相关关系，联合激素缺乏对骨龄的影响更为显著。
目的：探討矮小癥患兒的病因分類及其骨齡落後情況。方法迴顧性分析2009年1月至2014年12月住院治療2132例矮小癥患兒的臨床資料。結果2132例矮小癥患兒中男1333例、女799例，平均年齡(9.03±3.04)歲，平均骨齡(6.81±3.05歲)；完全性生長激素缺乏癥324例(15.20%)，部分性生長激素缺乏癥780例(36.58%)，多垂體激素缺乏癥27例(1.27%)，甲狀腺功能減低癥13例(0.61%)，特髮性矮小893例(41.89%)，低齣生體質量兒19例(0.89%)；骨骼髮育障礙8例(0.38%)，顱內腫瘤13例(0.61%)，慢性繫統性疾病15例(0.70%)，染色體疾病40例(1.88%)。ANOVA分析顯示，不同病因組骨齡落後情況不同，多垂體激素缺乏癥、顱內腫瘤導緻的矮小癥骨齡落後較其餘各病因組明顯。生長激素峰值與骨齡落後值之間存在負相關關繫。結論生長激素缺乏癥是矮小癥最常見病因。矮小癥患兒普遍存在骨齡落後，骨齡落後值與生長激素峰值之間存在負相關關繫，聯閤激素缺乏對骨齡的影響更為顯著。
목적：탐토왜소증환인적병인분류급기골령락후정황。방법회고성분석2009년1월지2014년12월주원치료2132례왜소증환인적림상자료。결과2132례왜소증환인중남1333례、녀799례，평균년령(9.03±3.04)세，평균골령(6.81±3.05세)；완전성생장격소결핍증324례(15.20%)，부분성생장격소결핍증780례(36.58%)，다수체격소결핍증27례(1.27%)，갑상선공능감저증13례(0.61%)，특발성왜소893례(41.89%)，저출생체질량인19례(0.89%)；골격발육장애8례(0.38%)，로내종류13례(0.61%)，만성계통성질병15례(0.70%)，염색체질병40례(1.88%)。ANOVA분석현시，불동병인조골령락후정황불동，다수체격소결핍증、로내종류도치적왜소증골령락후교기여각병인조명현。생장격소봉치여골령락후치지간존재부상관관계。결론생장격소결핍증시왜소증최상견병인。왜소증환인보편존재골령락후，골령락후치여생장격소봉치지간존재부상관관계，연합격소결핍대골령적영향경위현저。
ObjectiveThe aim of this study is to analyze the etiology and status of bone age of children with short stat-ure.MethodsAnthropological and physical examination data were retrospectively collected and studied in 2132 children with short stature in the department of endocrinology between 2009 and 2014. Growth hormone (GH) levels were determined by ar-ginine-clonidine test. Bone age was determined by CHN scoring.ResultsAmong the 2132 patients, 1333 were males and 799 were females. Mean age is 9.03 ± 3.04 years old, mean bone age is 6.81 ± 3.05 years. Of them, 324 cases (15.2%) were diagnosed complete GH deifciency, 780 cases (36.59%) were partial GH deifciency, 27cases (1.27%) were multiple pituitary hormone de-ifciency, 13 cases (1.64%) were hypothyroidism, 893 cases (41.89%) were idiopathic short stature, 19 cases (0.89%) were small for gestational age (SGA), 40 cases (1.88%) were chromosomal disorders, etc. Signiifcant difference in age and bone age was found using t test (P<0.05). Signiifcant differences in Δage were found between etiological categories using ANOVA (P=0.000). Δage was signiifcantly and negatively associated with peak GH using Pearson's correlation.ConclusionsGH deifciency is the most common cause of short stature. Bone age of children with short stature is commonly delayed. Δage was signiifcantly and negatively associated with peak GH. Multiple pituitary hormone deifciency has a signiifcant effect on bone age. The etiology of patients with short stature cannot be determined just by bone age.
