临床肾脏病杂志
臨床腎髒病雜誌
림상신장병잡지
JOURNAL OF CLINICAL NEPHROLOGY
2015年
7期
397-400
,共4页
微炎症状态%C反应蛋白%腹膜透析%铁代谢
微炎癥狀態%C反應蛋白%腹膜透析%鐵代謝
미염증상태%C반응단백%복막투석%철대사
Microinflammatory state%C-reactive protein%Peritoneal dialysis%Iron metabolism
目的：分析腹膜透析患者的C反应蛋白(C-reactive protein,CRP)与铁代谢相关指标间的相关性,探讨微炎症状态(microinflammatory state,MS)对腹膜透析患者铁代谢状态评估的影响。方法选择我院规律随访的持续性非卧床腹膜透析(continuous ambulatory peritoneal dialysis, CAPD)患者79例,记录患者年龄、性别、透析时间、收缩压、舒张压,计算尿素清除指数(Kt/V),检测血红蛋白、CRP、血清铁(serum iron,SI)、转铁蛋白饱和度(transferrin saturation,TSAT)、血清铁蛋白(serum ferritin,SF)、血白蛋白、血肌酐、尿素氮。根据患者的 CRP 水平分为 A组(CRP≤8 mg/L)和B组(CRP>8 mg/L)；并根据患者的 SF水平分为 C 组(SF<500μg/L)和 D 组(SF≥500μg/L),应用t检验分别比较 A 组与 B 组间年龄、性别、透析时间、收缩压、舒张压、Kt/V 值、血红蛋白、SI、TSAT、SF、血白蛋白、血肌酐、尿素氮等指标的差异,以及 C 组与 D 组间年龄、性别、透析时间、收缩压、舒张压、Kt/V值、血红蛋白、CRP、SI、TSAT、血白蛋白、血肌酐、尿素氮等指标的差异。采用Pear-son相关分析,分析患者的 CRP 水平与 SI、TSAT、SF和收缩压、舒张压水平的相关性。结果①与A组比较,B组患者的 SF水平显著升高(t=2.976,P<0.01),SI、TSAT、收缩压和舒张压水平降低(分别为t=3.743,P<0.01；t=2.420,P=0.018；t=2.181,P=0.032；t=2.328,P=0.023),血红蛋白水平(t=0.680,P=0.498)差异无统计学意义。②C 组与 D 组间比较年龄、性别、透析时间、收缩压、舒张压、Kt/V值、血红蛋白、CRP、SI、TSAT、血白蛋白、血肌酐、尿素氮差异均无统计学意义(P>0.05)。③CRP与 SF呈正相关(r=0.460,P<0.01),与 SI呈负相关(r=-0.350,P=0.002)。结论腹膜透析患者的铁代谢指标受到MS的影响,需要联合检测SI、TSAT、SF以及CRP水平以正确评估患者的铁代谢状态。
目的：分析腹膜透析患者的C反應蛋白(C-reactive protein,CRP)與鐵代謝相關指標間的相關性,探討微炎癥狀態(microinflammatory state,MS)對腹膜透析患者鐵代謝狀態評估的影響。方法選擇我院規律隨訪的持續性非臥床腹膜透析(continuous ambulatory peritoneal dialysis, CAPD)患者79例,記錄患者年齡、性彆、透析時間、收縮壓、舒張壓,計算尿素清除指數(Kt/V),檢測血紅蛋白、CRP、血清鐵(serum iron,SI)、轉鐵蛋白飽和度(transferrin saturation,TSAT)、血清鐵蛋白(serum ferritin,SF)、血白蛋白、血肌酐、尿素氮。根據患者的 CRP 水平分為 A組(CRP≤8 mg/L)和B組(CRP>8 mg/L)；併根據患者的 SF水平分為 C 組(SF<500μg/L)和 D 組(SF≥500μg/L),應用t檢驗分彆比較 A 組與 B 組間年齡、性彆、透析時間、收縮壓、舒張壓、Kt/V 值、血紅蛋白、SI、TSAT、SF、血白蛋白、血肌酐、尿素氮等指標的差異,以及 C 組與 D 組間年齡、性彆、透析時間、收縮壓、舒張壓、Kt/V值、血紅蛋白、CRP、SI、TSAT、血白蛋白、血肌酐、尿素氮等指標的差異。採用Pear-son相關分析,分析患者的 CRP 水平與 SI、TSAT、SF和收縮壓、舒張壓水平的相關性。結果①與A組比較,B組患者的 SF水平顯著升高(t=2.976,P<0.01),SI、TSAT、收縮壓和舒張壓水平降低(分彆為t=3.743,P<0.01；t=2.420,P=0.018；t=2.181,P=0.032；t=2.328,P=0.023),血紅蛋白水平(t=0.680,P=0.498)差異無統計學意義。②C 組與 D 組間比較年齡、性彆、透析時間、收縮壓、舒張壓、Kt/V值、血紅蛋白、CRP、SI、TSAT、血白蛋白、血肌酐、尿素氮差異均無統計學意義(P>0.05)。③CRP與 SF呈正相關(r=0.460,P<0.01),與 SI呈負相關(r=-0.350,P=0.002)。結論腹膜透析患者的鐵代謝指標受到MS的影響,需要聯閤檢測SI、TSAT、SF以及CRP水平以正確評估患者的鐵代謝狀態。
목적：분석복막투석환자적C반응단백(C-reactive protein,CRP)여철대사상관지표간적상관성,탐토미염증상태(microinflammatory state,MS)대복막투석환자철대사상태평고적영향。방법선택아원규률수방적지속성비와상복막투석(continuous ambulatory peritoneal dialysis, CAPD)환자79례,기록환자년령、성별、투석시간、수축압、서장압,계산뇨소청제지수(Kt/V),검측혈홍단백、CRP、혈청철(serum iron,SI)、전철단백포화도(transferrin saturation,TSAT)、혈청철단백(serum ferritin,SF)、혈백단백、혈기항、뇨소담。근거환자적 CRP 수평분위 A조(CRP≤8 mg/L)화B조(CRP>8 mg/L)；병근거환자적 SF수평분위 C 조(SF<500μg/L)화 D 조(SF≥500μg/L),응용t검험분별비교 A 조여 B 조간년령、성별、투석시간、수축압、서장압、Kt/V 치、혈홍단백、SI、TSAT、SF、혈백단백、혈기항、뇨소담등지표적차이,이급 C 조여 D 조간년령、성별、투석시간、수축압、서장압、Kt/V치、혈홍단백、CRP、SI、TSAT、혈백단백、혈기항、뇨소담등지표적차이。채용Pear-son상관분석,분석환자적 CRP 수평여 SI、TSAT、SF화수축압、서장압수평적상관성。결과①여A조비교,B조환자적 SF수평현저승고(t=2.976,P<0.01),SI、TSAT、수축압화서장압수평강저(분별위t=3.743,P<0.01；t=2.420,P=0.018；t=2.181,P=0.032；t=2.328,P=0.023),혈홍단백수평(t=0.680,P=0.498)차이무통계학의의。②C 조여 D 조간비교년령、성별、투석시간、수축압、서장압、Kt/V치、혈홍단백、CRP、SI、TSAT、혈백단백、혈기항、뇨소담차이균무통계학의의(P>0.05)。③CRP여 SF정정상관(r=0.460,P<0.01),여 SI정부상관(r=-0.350,P=0.002)。결론복막투석환자적철대사지표수도MS적영향,수요연합검측SI、TSAT、SF이급CRP수평이정학평고환자적철대사상태。
Objective To analyze the correlation between C-reactive protein (CRP)and indica-tors of iron metabolism,and explore the effect of microinflammatory state on iron metabolism in peri-toneal dialysis patients.Methods Seventy-nine patients undergoing continuous ambulatory peritoneal dialysis (CAPD)from our hospital were enrolled in the study.The data of age,sex,PD duration, systolic blood pressure (SBP),diastolic blood pressure (DBP),Kt/V,hemoglobin,CRP,serum iron (SI),transferrin saturation (TSAT),serum ferritin (SF),serum albumin,serum creatinine,and u-rea nitrogen were collected.The patients were divided into group A (CRP≤8 mg/L)and group B (CRP>8 mg/L)according to the levels of CRP.The patients were also divided into group C (SF<500μg/L)and group D (SF≥500μg/L)according to the levels of SF.Comparison of data between groups (A and B,or C and D)was performed using the Student t-test for continuous parametric data. The correlation between CRP and SI,TSAT,SF,SBP or DBP was analyzed by Pearson correlation a-nalysis.Results (1 )As compared with group A,the levels of SF were significantly increased (t=-2.976,P<0.01),and those of SI,TSAT,SBP and DBP were significantly decreased in group B (t=3.743,P<0.01;t=2.420,P=0.018;t=2.181,P=0.032;t=2.328,P=0.023 respectively). There was no significant difference in hemoglobin between group A and group B (t=0.680,P=0.498).(2)No significant difference was found in the clinical data between group C and group D such as age,sex,PD duration,SBP,DBP,Kt/V,hemoglobin,CRP,SI,TSAT,serum albumin,serum creatinine,and urea nitrogen.(3)Pearson correlation analysis revealed that CRP had a positive corre-lation with SF (r=0.460,P<0.01)and a negative correlation with SI (r=-0.350,P=0.002). Conclusions The indicators of iron metabolism are constantly affected by microinflammatory state in CAPD patients.Therefore,the combined tests of SI,TSAT,SF and CRP may favor the correct as-sessment of iron metabolism state.
