CAJ | 학술논문

目的：评价N末端B型钠尿肽原(NT-proBNP)和肌酸激酶同工酶MB(CK-MB)诊断肺炎患儿心力衰竭的价值。方法检测132例肺炎合并心力衰竭、138例肺炎未合并心力衰竭患儿和61例健康儿童的血清NT-proBNP和CK-MB水平。以受试者工作特征(ROC)曲线分析法和logistic回归分析评价NT-proBNP和CK-MB对诊断肺炎患儿心力衰竭的价值。结果三组间血清NT-proBNP和CK-MB水平差异有统计学意义(P<0.01)；肺炎合并心力衰竭患儿最高，其次为肺炎未合并心力衰竭患儿，三组间两两比较差异均有统计学意义(P均<0.01)。血清NT-proBNP和CK-MB在肺炎患儿中诊断心力衰竭的曲线下面积分别为0.85和0.72，两者联合诊断的曲线下面积为0.87。结论在肺炎患儿中，血清NT-proBNP和CK-MB可以作为辅助诊断心力衰竭的指标。
목적：평개N말단B형납뇨태원(NT-proBNP)화기산격매동공매MB(CK-MB)진단폐염환인심력쇠갈적개치。방법검측132례폐염합병심력쇠갈、138례폐염미합병심력쇠갈환인화61례건강인동적혈청NT-proBNP화CK-MB수평。이수시자공작특정(ROC)곡선분석법화logistic회귀분석평개NT-proBNP화CK-MB대진단폐염환인심력쇠갈적개치。결과삼조간혈청NT-proBNP화CK-MB수평차이유통계학의의(P<0.01)；폐염합병심력쇠갈환인최고，기차위폐염미합병심력쇠갈환인，삼조간량량비교차이균유통계학의의(P균<0.01)。혈청NT-proBNP화CK-MB재폐염환인중진단심력쇠갈적곡선하면적분별위0.85화0.72，량자연합진단적곡선하면적위0.87。결론재폐염환인중，혈청NT-proBNP화CK-MB가이작위보조진단심력쇠갈적지표。
ObjectiveTo investigate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and MB isoenzyme of creatine kinase (CK-MB) for heart failure (HF) in pneumonia children.MethodsThe NT-proBNP and CK-MB were assayed in 132 pneumonia children with HF, 138 pneumonia children without HF and 62 healthy children were recruited into this study. A receiver operating characteristics (ROC) curve and a logistic regression model were employed to assess the diagnostic accuracy of NT-proBNP and CK-MB for HF in pneumonia children.ResultsPneumonia children with HF had higher blood NT-proBNP and CK-MB than those in pneumonia children without HF and healthy controls (P<0.01 for both). Pneumonia children with HF had higher blood NT-proBNP and CK-MB than the pneumonia children without HF. The area under curves (AUCs) of NT-proBNP and CK-MB for HF were 0.85 and 0.72, respectively. The AUC for their combinational usage was 0.87.ConclusionBoth NT-proBNP and CK-MB are effective markers as diagnostic adjuncts for HF in pneumonia children. Combination of NT-proBNP and CK-MB can improve the diagnostic accuracy for HF in pneumonia children.