CAJ | 학술논문

高原红细胞增多症（HAPC）已成为严重威胁高原人群健康的主要常见慢性疾病之一。在藏医药经典古籍《四部医典》中记载有该病的治疗方法及药物，具有疗效明确、副作用小等独特优势。本文对藏医药防治HAPC的病因病机、临床治疗优势和现代创新研究做了分析，并针对目前藏医药治疗HAPC临床有效性规范化不足、藏药复方的药效物质基础与作用机制不清楚等问题，提出在继承藏医药理论基础上，以临床疗效为根本，将藏医药原创思维与现代科技结合，加强藏医药治疗HAPC古籍文献整理与用药经验数据挖掘，规范临床治疗标准和用药方案，以代谢组学等系统生物学现代研究手段，进一步研究藏医药治疗HAPC的科学内涵。
고원홍세포증다증（HAPC）이성위엄중위협고원인군건강적주요상견만성질병지일。재장의약경전고적《사부의전》중기재유해병적치료방법급약물，구유료효명학、부작용소등독특우세。본문대장의약방치HAPC적병인병궤、림상치료우세화현대창신연구주료분석，병침대목전장의약치료HAPC림상유효성규범화불족、장약복방적약효물질기출여작용궤제불청초등문제，제출재계승장의약이론기출상，이림상료효위근본，장장의약원창사유여현대과기결합，가강장의약치료HAPC고적문헌정리여용약경험수거알굴，규범림상치료표준화용약방안，이대사조학등계통생물학현대연구수단，진일보연구장의약치료HAPC적과학내함。
High altitude polycythemia (HAPC) had become one of the main common chronic diseases, which had seriously threatened the health of Plateau people. In the Tibetan medicine classic bookSi-Bu Yi-Dian, there were recordings on HAPC treatment methods and medications, which had the unique advantages of identified therapeutic effect with little side effect. This article analyzed Tibetan medicine in the prevention and treatment of HAPC from aspects such as etiology and pathogenesis, clinical treatment advantages and modern innovation study. Questions were also raised on lacking of standardization on HAPC clinical effectiveness, as well as Tibetan medicine compound material basis and action mechanisms were unclear. It was proposed that based on the inheritance of Tibetan medicine theoretical basis and clinical therapeutic effect, the Tibetan medicine original thinking should be combined with modern science and technology, in order to strengthen the analysis of ancient literature collection in HAPC treatment and data mining in medication experiences. The clinical treatment standards and medication plan should be standardized. Methods of systems biology, such as metabolomics, can be used in the further study of the scientific connotation of HAPC treatment by Tibetan medicine.