CAJ | 학술논문

目的：观察巴曲酶联合甲泼尼龙治疗突发性耳聋的临床效果。方法回顾性地分析2012年8月至2014年10月在解放军总医院海南分院耳鼻咽喉头颈外科就诊的110例（共118耳）突发性耳聋患者的资料，观察组57人（62耳）治疗方案中含巴曲酶、甲泼尼龙；对照组53人（56耳）治疗方案中不含巴曲酶、甲泼尼龙。根据纯音听阈图形将患者分为4组，中低频听力下降38耳、中高频听力下降51耳、平坦型12耳、全聋型17耳。结果观察组经治疗后痊愈11耳（17.7%）、显效32耳（51.6%）、有效16耳（25.8%）、无效3耳（4.8%），总有效率95.16%；对照组治疗后痊愈6耳（10.7%）、显效21耳（37.5%）、有效20耳（35.7%）、无效9耳（16.1%），总有效率83.93%。两组比较差异具有统计学意义（P＜0.05）。中低频听力下降型耳聋预后最好、平坦型耳聋预后较好、中高频听力下降型耳聋预后较差、全聋型预后最差，两组有效率比较差异均具有统计学意义（P＜0.05）。结论巴曲酶联合甲泼尼龙治疗突发性耳聋具有满意的临床效果，且安全可靠，值得临床推广，不同类型的突发性耳聋预后差别很大。
목적：관찰파곡매연합갑발니룡치료돌발성이롱적림상효과。방법회고성지분석2012년8월지2014년10월재해방군총의원해남분원이비인후두경외과취진적110례（공118이）돌발성이롱환자적자료，관찰조57인（62이）치료방안중함파곡매、갑발니룡；대조조53인（56이）치료방안중불함파곡매、갑발니룡。근거순음은역도형장환자분위4조，중저빈은력하강38이、중고빈은력하강51이、평탄형12이、전롱형17이。결과관찰조경치료후전유11이（17.7%）、현효32이（51.6%）、유효16이（25.8%）、무효3이（4.8%），총유효솔95.16%；대조조치료후전유6이（10.7%）、현효21이（37.5%）、유효20이（35.7%）、무효9이（16.1%），총유효솔83.93%。량조비교차이구유통계학의의（P＜0.05）。중저빈은력하강형이롱예후최호、평탄형이롱예후교호、중고빈은력하강형이롱예후교차、전롱형예후최차，량조유효솔비교차이균구유통계학의의（P＜0.05）。결론파곡매연합갑발니룡치료돌발성이롱구유만의적림상효과，차안전가고，치득림상추엄，불동류형적돌발성이롱예후차별흔대。
ObjectiveTo observe the clinical efficiency of batroxobin combined with methylprednisolone in the treatment of sudden hearing loss.Methods A retrospective analysis was performed on 110 patients with (118 ears) sudden deafness in the Hainan Branch of Chinese PLA General Hospital from August 2012 to October 2014. According to their treatment regimen, they were assigned into observation group (n=57, 62 ears, conventional treatment plus batroxobin and methylprednisolone) and control group (n=53, 56 ears, only conventional treatment). The cohort was also divided into 4 groups according to the pure tone hearing threshold graphics, that is, low frequency hearing loss (38 ears), high frequency hearing loss (51 ears), flat type (12 ears), and total deafness (17 ears).Results After treatment, the observation group had 11 ears (17.7%) recovered, 32 ears (51.6%) markedly effective, 16 ears (25.8%) effective, and 3 ears (4.8%)invalid, with a total efficiency rate of 95.16%. There were 6 ears (10.7%) recovered, 21 ears (37.5%) markedly effective, 20 ears (35.7%) effective, and 9 ears (16.1%) invalid in the control group (total efficiency rate 83.93%). Significant difference was seen in the total efficiency rate between 2 groups (P<0.05). Low frequency hearing loss type deafness had better prognosis, flat type deafness had good, high frequency hearing loss type deafness had bad, and total deafness type hearing loss type deafness had worst prognosis. There were significant differences in the efficiency of different treatment regimen for different deafness types between 2 groups (P<0.05).Conclusion Combination of batroxobin and methylprednisolone is efficient and safe in the treatment of sudden hearing loss, and worthy of clinical promotion. Different types of sudden deafness have widely various prognosis.