CAJ | 학술논문

相思子蛋白（Abrin）是自相思子（Aburs precatorius L.）种子中分离的一种细胞毒性蛋白。本文从Abrin的分子结构和毒性、抗肿瘤作用特点、抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、增强机体免疫功能5个方面，阐述近几年来Abrin抗肿瘤作用及其作用机制，同时从免疫毒素靶向治疗和纳米制剂的研究两方面阐述了Abrin的应用前景，有助于对Abrin的进一步研究和利用，并为发现新的抗肿瘤药物靶点提供科学依据。
상사자단백（Abrin）시자상사자（Aburs precatorius L.）충자중분리적일충세포독성단백。본문종Abrin적분자결구화독성、항종류작용특점、억제종류세포증식、유도종류세포조망、증강궤체면역공능5개방면，천술근궤년래Abrin항종류작용급기작용궤제，동시종면역독소파향치료화납미제제적연구량방면천술료Abrin적응용전경，유조우대Abrin적진일보연구화이용，병위발현신적항종류약물파점제공과학의거。
Abrin is isolated from abrin seeds (Aburs precatoriusL.), which is a kind of cytotoxic protein. This article reviewed the anticancer effect and mechanisms of Abrin from five aspects in several years, which were the molecular structure and toxicity of Abrin, the characteristics of Abrin in anticancer effect, the role of Abrin in inhibiting cancer cell proliferation, the mechanisms of Abrin induced apoptosis of cancer cells, the anticancer mechanisms of Abrin in enhancing immune function. And the application prospect of Abrin immunotoxin targeted therapy and nano preparation will be expounded in this article. It will be helpful to further research about application on Abrin. It will provide the scientific basis for discovering new drug targets of cancer.