CAJ | 학술논문

研究表明2型糖尿病可能增加肺癌发生的风险，但其尚缺乏有力的相关机制研究。本文从2型糖尿病和肺癌间的流行病学特点、2型糖尿病患者的肺癌发病率升高、高血糖、胰岛素抵抗、高胰岛素血症、胰岛素样生长因子、血管内皮生长因子、炎症细胞因子、激素调节功能紊乱、免疫系统功能降低、微量元素及降糖药物等方面综述二者可能的相关性，但2型糖尿病加重肺癌的机制仍需要大量研究证明。
연구표명2형당뇨병가능증가폐암발생적풍험，단기상결핍유력적상관궤제연구。본문종2형당뇨병화폐암간적류행병학특점、2형당뇨병환자적폐암발병솔승고、고혈당、이도소저항、고이도소혈증、이도소양생장인자、혈관내피생장인자、염증세포인자、격소조절공능문란、면역계통공능강저、미량원소급강당약물등방면종술이자가능적상관성，단2형당뇨병가중폐암적궤제잉수요대량연구증명。
Some researches have shown that type 2 diabetes mellitus may increase the risk of lung cancer. However, it is still lack of effective evidence on the underlying mechanism. This article reviewed that their epidemiological characteristics, hyperglycemia, insulin resistance and hyperinsulinemia, insulin and insulin-like growth factor, vascular endothelial growth factor, inflammatory cytokines, disorder of hormones regulating function, reduced immune system function, disorder of trace elements and the glucose-lowering therapies in diabetes patients may be associated with an increased incidence of lung cancer. However, more studies are needed to further investigate the mechanism urderlying type 2 diabetes mellitus promoting the incidence of lung cancer.