CAJ | 학술논문

益生菌是一类能使其宿主获益的活体微生物，应用广泛，但目前并没有大数据支持其临床应用。很多临床研究证实了不同益生菌防治抗生素相关性腹泻（AAD）的有效性，但基于近年的数据，回答益生菌是否可降低老年人AAD发生率的科学依据尚显薄弱。总的来说，益生菌有着非常好的安全记录，特定人群包括AAD患者使用益生菌将会获益，但需要个体化。
익생균시일류능사기숙주획익적활체미생물，응용엄범，단목전병몰유대수거지지기림상응용。흔다림상연구증실료불동익생균방치항생소상관성복사（AAD）적유효성，단기우근년적수거，회답익생균시부가강저노년인AAD발생솔적과학의거상현박약。총적래설，익생균유착비상호적안전기록，특정인군포괄AAD환자사용익생균장회획익，단수요개체화。
Probiotics are living microbes which may give health benefit to the host. Despite their wide usage, the clinical use of probiotics lacks support from reasonable big data. Dozens of clinical studies have reported that probiotics are a promising strategy for the prevention and treatment of antibiotic-associated diarrhea (AAD). However, based on data from recent randomized controlled trials, it is hard to give a positive answer to whether probiotics could decrease the incidence of AAD in the elderly. Up till now, probiotics have a very good safety record. The use of probiotics may be beneficial for certain elderly patients including AAD, while needs be considered individually.