CAJ | 학술논문

血管新生是肿瘤生长、侵袭、转移过程中的一个重要环节，以肿瘤新生血管为靶向的肿瘤治疗策略已成为目前肿瘤学研究的热点。肿瘤血管生成的信号传导是一个复杂、多因素、多途径、交叉的网络系统，针对某一个单一靶点往往不足以遏制或扭转其结构的高度异质及形态异常。因此，不同作用通路和机制的药物多靶点联合作用于肿瘤血管生成的信号通路，将是今后一个重要的研究方向。大量实验研究发现，许多补气活血药配伍在肿瘤新生血管生成中能发挥多靶点、多途径的调节作用，作用于肿瘤血管生成的不同环节而发挥抗肿瘤侵袭、转移作用，在治疗肿瘤及新生血管方面具有广阔的研究前景。
혈관신생시종류생장、침습、전이과정중적일개중요배절，이종류신생혈관위파향적종류치료책략이성위목전종류학연구적열점。종류혈관생성적신호전도시일개복잡、다인소、다도경、교차적망락계통，침대모일개단일파점왕왕불족이알제혹뉴전기결구적고도이질급형태이상。인차，불동작용통로화궤제적약물다파점연합작용우종류혈관생성적신호통로，장시금후일개중요적연구방향。대량실험연구발현，허다보기활혈약배오재종류신생혈관생성중능발휘다파점、다도경적조절작용，작용우종류혈관생성적불동배절이발휘항종류침습、전이작용，재치료종류급신생혈관방면구유엄활적연구전경。
Angiogenesis is an important link of tumor growth, invasion and metastasis. The tumor angiogenesis targeting strategy for the treatment of cancer has become a hot spot in oncology research currently. Signal transduction of tumor angiogenesis is a complex, multi-factor, multi-way and cross network system. Treatment for a single target is often not sufficient to halt or reverse its highly heterogeneous structure and abnormal shape. Therefore, it will be an important research direction that the combination of different pathways and mechanisms of medications effect on signaling pathway in tumor angiogenesis by multi-target. A number of experimental studies found that qi-reinforcing and blood-activating medication can play a regulating role of multiple targets, multiple pathways in tumor angiogenesis. It had different effect on tumor angiogenesis against tumor invasion and metastasis.Qi-reinforcing and blood-activating medication will have broad prospects in the treatment of tumor and angiogenesis.