CAJ | 학술논문

为寻找新型的深度脑刺激（DBS）刺激波形和简化DBS参数设置，提出基于脉宽调制PWM思想调制DBS波形的方案。利用正弦波等效的PWM（SPWM）形成一种新的DBS波形，并通过帕金森病网络模型验证了SPWM DBS的作用效果。仿真结果显示SPWM DBS与普通的周期性脉冲DBS作用效果一致，使帕金森病的病态放电恢复正常。SPWM调制波幅值是影响SPWM DBS作用效应的关键参数，通过调整调制波幅值可以优化DBS的能量。
위심조신형적심도뇌자격（DBS）자격파형화간화DBS삼수설치，제출기우맥관조제PWM사상조제DBS파형적방안。이용정현파등효적PWM（SPWM）형성일충신적DBS파형，병통과파금삼병망락모형험증료SPWM DBS적작용효과。방진결과현시SPWM DBS여보통적주기성맥충DBS작용효과일치，사파금삼병적병태방전회복정상。SPWM조제파폭치시영향SPWM DBS작용효응적관건삼수，통과조정조제파폭치가이우화DBS적능량。
In order to search new Deep Brain Stimulation(DBS)waveform and simplify the process in setting DBS param-eters, a scheme that modulated the DBS waveform based on the principle of pulse width modulation(PWM)is proposed. A new DBS waveform is made by Sinusoidal PWM(SPWM)and a neuronal network model of Parkinson’s disease is introduced to test the effects of this SPWM DBS. Simulation results show that the effects of this SPWM DBS are identical to that of the periodic pulse DBS and can restore the pathological firing patterns from Parkinsonian state back to normal. The modulated wave amplitude of SPWM, through which DBS energy can be optimized, is the key parameter that influences the effects of SPWM DBS.