CAJ | 학술논문

目的：研究以乌司他丁联合应用参麦注射液治疗急性重症胰腺炎，比较患者单独和联合用药的疗效。方法选取2010年至2013年间收治的急性重症胰腺炎患者40例，随机分为两组：实验组（20例）予联合用药治疗，对照组（20例）予单独应用乌司他丁治疗。采用SPSS13．0软件分析，血尿淀粉酶和APACHEⅡ评分用（ x珋±s）表示，采用t检验；综合疗效评价以率（％）表示，采用χ2检验。 P＜0．05表示有统计学意义。结果两组患者治疗前，治疗后10 d血尿淀粉酶各指标，差异均无统计学意义；而治疗后5 d、7 d两组差异有统计学意义（ t＝2．522、3．526、3．051、3．142， P＜0．05）。5 d、7 d APACHEⅡ评分，实验组（12±4．4）、（8．1±3．4），对照组（15．4±4．3）、（12．7±3．3）各组指标均数对比实验组效果优于对照组，差异均有统计学意义（t＝2．639、2．198， P＜0．05）。实验组总有效率为95．0％（19／20）明显高于对照组60．0％（12／20），差异有统计学意义（χ2＝7．03， P＜0．05），表明联合用药疗效较单独应用乌司他丁疗效好。结论对于急性重症胰腺炎，乌司他丁与参麦注射液联合应用可控制病情的发展、提高治愈率，有重要临床意义，值得推广。
목적：연구이오사타정연합응용삼맥주사액치료급성중증이선염，비교환자단독화연합용약적료효。방법선취2010년지2013년간수치적급성중증이선염환자40례，수궤분위량조：실험조（20례）여연합용약치료，대조조（20례）여단독응용오사타정치료。채용SPSS13．0연건분석，혈뇨정분매화APACHEⅡ평분용（ x류±s）표시，채용t검험；종합료효평개이솔（％）표시，채용χ2검험。 P＜0．05표시유통계학의의。결과량조환자치료전，치료후10 d혈뇨정분매각지표，차이균무통계학의의；이치료후5 d、7 d량조차이유통계학의의（ t＝2．522、3．526、3．051、3．142， P＜0．05）。5 d、7 d APACHEⅡ평분，실험조（12±4．4）、（8．1±3．4），대조조（15．4±4．3）、（12．7±3．3）각조지표균수대비실험조효과우우대조조，차이균유통계학의의（t＝2．639、2．198， P＜0．05）。실험조총유효솔위95．0％（19／20）명현고우대조조60．0％（12／20），차이유통계학의의（χ2＝7．03， P＜0．05），표명연합용약료효교단독응용오사타정료효호。결론대우급성중증이선염，오사타정여삼맥주사액연합응용가공제병정적발전、제고치유솔，유중요림상의의，치득추엄。
Objective To investigate the curative effect of severe acute pancreatitis (SAP) by using ulinastin and/or Shenmai injection . Methods From 2010 to 2013, 40 patients with SAP were treated in our hospital.They were randomly divided into two groups: experimental group (20 patients) and control group ( 20 patients ) . The experimental group received combined therapy with ulinastin and Shenmai injection, and the control group was subjected to single-drug therapy.SPSS13.0 software was used to analyze clinical data including biood/urine amylase and APACHEⅡscore.The data were measured as mean ±SD and compared using independent samples t test .Total effective rate (%) was compared by using the Chi-square test.A P value less than 0.05 was considered statistically significant . Results There was no statistically significant difference between the two groups , including biood/urine amylase before and 10 days after treatment.However there was significant difference between the two groups at 5 days and 7 days after treatment(t=2.522、3.526、3.051 and 3.142 respectively, P<0.05).APACHEⅡscores at 5 days and 7 days after treatment in the exprerimental group were (12 ±4.4) and (8.1 ±3.4) respectively, whereas in the control group (15.4 ±4.3) and (12.7 ±3.3) respectively, with significant difference between the two groups (t=2.639, 2.198, P﹤0.05).The total effective rate in the exprerimental group was 95.0%(19/20), but in control group 60.0% (12/20), with a significant difference (χ2 =7.03, P <0.05). Conclusion Combined ulinastin and Shenmai injection proved to be effective in treating SAP .The regimen could slow down the process of SAP in early stage and improve the recovery rate .Combined ulinastin and Shenmai injection is worth popularizing in the treatment of SAP .