世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2015年
6期
1215-1219
,共5页
保留灌肠%慢性前列腺炎%细胞因子%血流变%临床对照
保留灌腸%慢性前列腺炎%細胞因子%血流變%臨床對照
보류관장%만성전렬선염%세포인자%혈류변%림상대조
Retention enema%chronic prostatitis%cytokines%hemorrheology%controlled clinical trials
目的：依托观察慢性前列腺炎患者治疗前后炎症介质及血流变的变化，比较祛瘀通闭汤规范保留灌肠对慢性前列腺炎和使用α-受体阻滞剂和喹诺酮类抗生素联合治疗的疗效差异性。方法：将同期在河南省中医院就诊的164例患者随机分为观察组和对照组，每组62例，观察组使用祛瘀通闭汤规范保留灌肠治疗慢性前列腺炎，对照组使用α-受体阻滞剂和喹诺酮类抗生素联合治疗。疗程1月，对比两者差异性。结果：观察组总有效率为79.03%（49例），与对照组总有效率61.29%（39例）相比，差异有统计学意义（P<0.05）；两组患者治疗前后TNF-α、IFN-γ及NIH-CPSI评分对比，差异有统计学意义（P<0.05），与对照组比较，观察组治疗后TNF-α、IFN-γ及NIH-CPSI评分差异显著（P<0.01）；对照组治疗前后全血粘度（高切）、血浆粘度和红细胞压积测试值对比均无明显差异。观察组治疗前后全血粘度（高切）和血浆粘度测试值对比，差异有统计学意义（P<0.05），但红细胞压积测试值对比无明显差异。结论：两种治疗方法对于慢性前列腺炎均具有一定疗效，但是祛瘀通闭汤规范保留灌肠治疗慢性前列腺炎的疗效明显优于喹诺酮类抗生素合并α-受体阻滞剂方式。
目的：依託觀察慢性前列腺炎患者治療前後炎癥介質及血流變的變化，比較祛瘀通閉湯規範保留灌腸對慢性前列腺炎和使用α-受體阻滯劑和喹諾酮類抗生素聯閤治療的療效差異性。方法：將同期在河南省中醫院就診的164例患者隨機分為觀察組和對照組，每組62例，觀察組使用祛瘀通閉湯規範保留灌腸治療慢性前列腺炎，對照組使用α-受體阻滯劑和喹諾酮類抗生素聯閤治療。療程1月，對比兩者差異性。結果：觀察組總有效率為79.03%（49例），與對照組總有效率61.29%（39例）相比，差異有統計學意義（P<0.05）；兩組患者治療前後TNF-α、IFN-γ及NIH-CPSI評分對比，差異有統計學意義（P<0.05），與對照組比較，觀察組治療後TNF-α、IFN-γ及NIH-CPSI評分差異顯著（P<0.01）；對照組治療前後全血粘度（高切）、血漿粘度和紅細胞壓積測試值對比均無明顯差異。觀察組治療前後全血粘度（高切）和血漿粘度測試值對比，差異有統計學意義（P<0.05），但紅細胞壓積測試值對比無明顯差異。結論：兩種治療方法對于慢性前列腺炎均具有一定療效，但是祛瘀通閉湯規範保留灌腸治療慢性前列腺炎的療效明顯優于喹諾酮類抗生素閤併α-受體阻滯劑方式。
목적：의탁관찰만성전렬선염환자치료전후염증개질급혈류변적변화，비교거어통폐탕규범보류관장대만성전렬선염화사용α-수체조체제화규낙동류항생소연합치료적료효차이성。방법：장동기재하남성중의원취진적164례환자수궤분위관찰조화대조조，매조62례，관찰조사용거어통폐탕규범보류관장치료만성전렬선염，대조조사용α-수체조체제화규낙동류항생소연합치료。료정1월，대비량자차이성。결과：관찰조총유효솔위79.03%（49례），여대조조총유효솔61.29%（39례）상비，차이유통계학의의（P<0.05）；량조환자치료전후TNF-α、IFN-γ급NIH-CPSI평분대비，차이유통계학의의（P<0.05），여대조조비교，관찰조치료후TNF-α、IFN-γ급NIH-CPSI평분차이현저（P<0.01）；대조조치료전후전혈점도（고절）、혈장점도화홍세포압적측시치대비균무명현차이。관찰조치료전후전혈점도（고절）화혈장점도측시치대비，차이유통계학의의（P<0.05），단홍세포압적측시치대비무명현차이。결론：량충치료방법대우만성전렬선염균구유일정료효，단시거어통폐탕규범보류관장치료만성전렬선염적료효명현우우규낙동류항생소합병α-수체조체제방식。
Through observation on changes of inflammatory mediators and hemorrheology among chronic prostatitis patients before and after treatment, this study was aimed to compare the therapeutic differences between the applications of standard retention enema ofQu-Yu Tong-Bi (QYTB) decoction andα-blockers combined with quinolones. During the same period, 164 patients of the Henan Province of Traditional Chinese Medicine Hospital were randomly divided into the observation group and control group, with 62 cases in each group. Retention enema of QYTB decoction was given in the observation group; andα-blockers combined with quinolones were used in the control group. The treatment course was one month. And the differences were compared. The results showed that the total effective rate of the observation group was 79.03% (49 cases); and that of the control group was 61.29%(39 cases). There was statistical significance between two groups (P < 0.05). There was statistical significance on TNF-α, IFN-γ and NIH-CPSI score comparison before and after treatment of two groups (P < 0.05). Compared to the control group, the posttreatment TNF-α, IFN-γ and NIH-CPSI score in the observation group had significant difference (P < 0.01). There were no significant differences on the whole blood viscosity (high shear), plasma viscosity and erythrocyte deposited test value contrast between pretreatment and posttreatment in the control group. There were significant differences on the whole blood viscosity (high shear) and plasma viscosity between pretreatment and posttreatment in the observation group (P < 0.05). However, there was no significant differences on erythrocyte deposited test value contrast. It was concluded that both methods had certain therapeutic effect in the treatment of chronic prostatitis. However, the effect of retention enema of QYTB decoction was better than the treatment of quinolones combined withα-blockers.
