中国中西医结合外科杂志
中國中西醫結閤外科雜誌
중국중서의결합외과잡지
CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2015年
4期
363-365
,共3页
心率变异性%辣椒素%疼痛%疼痛模型%自主神经系统
心率變異性%辣椒素%疼痛%疼痛模型%自主神經繫統
심솔변이성%랄초소%동통%동통모형%자주신경계통
Heart rate variability%capsaicin%pain%pain model%autonomic nervous system
目的：探讨心率变异性分析对辣椒素疼痛模型进行评价的可行性。方法：22~27岁健康志愿者36名，取平静状态20 min ECG信号中较稳定的一段长度5 min信号作为对照；以浸透0.5 mL辣椒素溶液的棉纸片覆盖下唇唇红位置，继续记录20 min心电信号，选取较稳定的一段长度5 min；记录涂抹辣椒素后的VAS评分；用Matlab R2006a编程软件分析所采集到的ECG信号，计算平静状态下（T0）和辣椒素刺激状态下（T1）的心率变异性（HRV）指标，进行统计学分析。结果：视觉模拟评分（VAS）平均（63.36±11.21），可评价为中度疼痛；心率在T1时期较T0时期增加，无统计学意义。HRV时域分析指标NN间期标准差（SDNN）、相邻NN间期差的均方根（RMSSD）在T1期均较T0期明显升高；HRV频域分析指标总功率（TP）、低频功率（LF）、高频功率（HF）以及LF/HF在T1期均较T0期明显升高；散点图分析结果：散点图短轴（SD1）和散点图长轴（SD2）在T1时期较T0时期均明显升高。结论：用辣椒素建立疼痛模型是可行的，且操作简单，易于实施；HRV分析有可能在疼痛的量化评价中具有一定权衡作用。
目的：探討心率變異性分析對辣椒素疼痛模型進行評價的可行性。方法：22~27歲健康誌願者36名，取平靜狀態20 min ECG信號中較穩定的一段長度5 min信號作為對照；以浸透0.5 mL辣椒素溶液的棉紙片覆蓋下脣脣紅位置，繼續記錄20 min心電信號，選取較穩定的一段長度5 min；記錄塗抹辣椒素後的VAS評分；用Matlab R2006a編程軟件分析所採集到的ECG信號，計算平靜狀態下（T0）和辣椒素刺激狀態下（T1）的心率變異性（HRV）指標，進行統計學分析。結果：視覺模擬評分（VAS）平均（63.36±11.21），可評價為中度疼痛；心率在T1時期較T0時期增加，無統計學意義。HRV時域分析指標NN間期標準差（SDNN）、相鄰NN間期差的均方根（RMSSD）在T1期均較T0期明顯升高；HRV頻域分析指標總功率（TP）、低頻功率（LF）、高頻功率（HF）以及LF/HF在T1期均較T0期明顯升高；散點圖分析結果：散點圖短軸（SD1）和散點圖長軸（SD2）在T1時期較T0時期均明顯升高。結論：用辣椒素建立疼痛模型是可行的，且操作簡單，易于實施；HRV分析有可能在疼痛的量化評價中具有一定權衡作用。
목적：탐토심솔변이성분석대랄초소동통모형진행평개적가행성。방법：22~27세건강지원자36명，취평정상태20 min ECG신호중교은정적일단장도5 min신호작위대조；이침투0.5 mL랄초소용액적면지편복개하진진홍위치，계속기록20 min심전신호，선취교은정적일단장도5 min；기록도말랄초소후적VAS평분；용Matlab R2006a편정연건분석소채집도적ECG신호，계산평정상태하（T0）화랄초소자격상태하（T1）적심솔변이성（HRV）지표，진행통계학분석。결과：시각모의평분（VAS）평균（63.36±11.21），가평개위중도동통；심솔재T1시기교T0시기증가，무통계학의의。HRV시역분석지표NN간기표준차（SDNN）、상린NN간기차적균방근（RMSSD）재T1기균교T0기명현승고；HRV빈역분석지표총공솔（TP）、저빈공솔（LF）、고빈공솔（HF）이급LF/HF재T1기균교T0기명현승고；산점도분석결과：산점도단축（SD1）화산점도장축（SD2）재T1시기교T0시기균명현승고。결론：용랄초소건립동통모형시가행적，차조작간단，역우실시；HRV분석유가능재동통적양화평개중구유일정권형작용。
Objective To verify the feasibility of the capsaicin pain model and to discuss the quantitative analysis of pain by heart rate variability. Methods Approved by the ethics committee, thirty-six healthy vol?unteers were selected with the age of 22 to 27 years. The volunteers lied on their back and calmed down for 20 minutes. Then capsaicin solution was daubed on their lips. Observation was taken for another 20 minutes. VAS scores were recorded after capsaicin stimulation. The ECG signals were analyzed by Matlab R2006a. The heart rate variability indicators of volunteers at the T0 (state of calm) and T1 (stimulated by capsaicin) were recorded. The differences between the two groups were compared and the results statistically analyzed. The second card (Sigma Tel c-major Audio) of the laptop (DELL INSPIRON 501) was used to collect the ECG of volunteers. Results The VAS scores after the stimulation of capsaicin was 63.36 ± 11.21. The hemodynamic features of pa?tients showed the contrast within the two groups, the value of HR at T1 was significantly increased (P>0.05). The results of time-domain analysis showed the value of SDNN and RMSSD at T1 significantly increased (P<0.05). Frequency-analysis showed the value of TP, LF, HF and LF/HF at T1 significantly increased (P<0.05). The result of scatter diagram showed the value of SD1 and SD2 at T1 significantly increased (P<0.05). Conclusion It is feasible to build the capsaicin pain model. During the stimulation of capsaicin, the action of the autonomic nerve has significantly increased. Both the sympathetic nerve and the pneumogastric nerve can be enhanced. The heart rate variability can be used as the indicator to the evaluation of pain.
